QuickView for cdc6 (gene)
- Gene Symbol:
- CDC6
Homo sapiens - Full name:
- cell division cycle 6
- Synonyms:
- CDC18L, HsCDC18, HsCDC6, MGORS5, cell division control protein 6 homolog, CDC6 cell division cycle 6 homolog, CDC6-related protein, cdc18-related protein, cell division cycle 6 homolog, p62(cdc6)
- Genomic Location:
- Chr 17: 35697672-35712939
- Description:
-
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular tran...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
E2F1_Q4_01 , E2F4DP1_01 , E2F_Q6_01 , E2F1_Q4 , E2F_Q6 , E2F_Q4 , E2F1DP2_01 , ACTAYRNNNCCCR_UNKNOWN , E2F_03 , YCATTAA_UNKNOWN
- Cytogenetic Map:
-
17q21.2
GO Molecular Function
sequence-specific DNA binding | kinase binding | enzyme binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | ATP binding | anion binding | adenyl nucleotide binding | DNA binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | double-stranded DNA binding | DNA replication origin binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of cyclin-dependent protein serine/threonine kinase activity | regulation of cell cycle process | regulation of cell cycle G1/S phase transition | positive regulation of G1/S transition of mitotic cell cycle | response to hormone | negative regulation of cellular process | positive regulation of fibroblast proliferation | regulation of G1/S transition of mitotic cell cycle | positive regulation of phosphate metabolic process | regulation of DNA replication | regulation of organelle organization | negative regulation of DNA metabolic process | regulation of chromosome segregation | cellular process | mitotic DNA integrity checkpoint | regulation of mitotic nuclear division | regulation of chromosome separation | positive regulation of protein kinase activity | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | negative regulation of cellular metabolic process | response to peptide hormone | positive regulation of cytokinesis | regulation of cellular process | regulation of metabolic process | positive regulation of cyclin-dependent protein kinase activity | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | DNA replication checkpoint | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | DNA-dependent DNA replication | DNA replication initiation | regulation of cell division | negative regulation of DNA replication | response to stimulus | regulation of mitotic cell cycle phase transition | positive regulation of protein metabolic process | negative regulation of G2/M transition of mitotic cell cycle | regulation of cell proliferation | response to peptide | regulation of cell cycle phase transition | cellular nitrogen compound metabolic process | mitotic DNA replication checkpoint | cell cycle G1/S phase transition | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | cellular biosynthetic process | regulation of nucleic acid-templated transcription | response to nitrogen compound | cellular response to hormone stimulus | regulation of cell cycle G2/M phase transition | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | negative regulation of mitotic cell cycle phase transition | negative regulation of cell cycle G2/M phase transition | cellular response to peptide hormone stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | cellular response to peptide | cellular response to vasopressin | cell cycle | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | biosynthetic process | cell division | regulation of cellular protein metabolic process | mitotic cell cycle phase transition | positive regulation of cell cycle G1/S phase transition | cellular response to angiotensin | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of cytokinesis | regulation of protein metabolic process | regulation of transcription involved in G1/S transition of mitotic cell cycle | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of mitotic cell cycle | positive regulation of molecular function | response to angiotensin | mitotic G2/M transition checkpoint | regulation of fibroblast proliferation | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | DNA metabolic process | regulation of sister chromatid segregation | positive regulation of mitotic cell cycle phase transition | mitotic cell cycle | response to vasopressin | metabolic process | regulation of RNA biosynthetic process | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | positive regulation of chromosome segregation | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of chromosome organization | negative regulation of cell cycle | regulation of mitotic sister chromatid segregation | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular macromolecule biosynthetic process | traversing start control point of mitotic cell cycle | positive regulation of cell cycle process | negative regulation of cell proliferation | regulation of mitotic metaphase/anaphase transition | response to organonitrogen compound | cell cycle phase transition | heterocycle metabolic process | positive regulation of metabolic process | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | cell cycle checkpoint | DNA replication | regulation of cellular component organization | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | cytoplasm | spindle | intracellular organelle | nucleoplasm | microtubule cytoskeleton | spindle pole | spindle midzone | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular
