QuickView for cdps (gene)

Gene Symbol:

CAPNS1 Homo sapiens

Full name:

calpain small subunit 1

Synonyms:

CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, calpain small subunit 1, CANP small subunit, calcium-activated neutral proteinase small subunit, calcium-dependent protease small subunit 1, calcium-dependent protease, small subunit, calpain 4, small subunit (30K), calpain regulatory subunit, calpain, small polypeptide

Genomic Location:

Chr 19: 41322758-41333095

Description:

This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit en...

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This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  AP1_Q6 ,  AP1_Q6_01 ,  AP1FJ_Q2 ,  ZID_01 ,  BACH2_01 ,  GGGCGGR_SP1_Q6 ,  AP1_Q4 ,  AP1_Q2 ,  RCGCANGCGY_NRF1_Q6

Cytogenetic Map:

19q13.12

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