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PubChem
| Name: | Cetirizine |
|---|---|
| PubChem Compound ID: | 150716 |
| Description: | A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. |
| Molecular formula: | C21H25ClN2O3 |
| Molecular weight: | 388.888 g/mol |
| Synonyms: |
NCGC00016949-01; CAS-83881-52-1
|
DrugBank
Identification
| Name: | Cetirizine |
|---|---|
| Name (isomeric): | DB00341 |
| Drug Type: | small molecule |
| Description: | A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects. |
| Synonyms: |
Cetirizina [Spanish]; Cetrizine Hcl; Cetirizinum [Latin]
|
| Brand: | Zyrtec-D, Formistin, Reactine, Alerlisin, Zirtek, Setir, Zyrtec, Hitrizin Film Tablet, Virlix, Ziptek, Zyrlex, Zyrtec Syrup, Cetryn |
| Category: | Antihistamines, Anti-Allergic Agents, Histamine H1 Antagonists, Non-Sedating |
| CAS number: | 83881-51-0 |
Pharmacology
| Indication: | For the relief of symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis and the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria |
|---|---|
| Pharmacology: | Cetirizine, the active metabolite of the piperazine H1-receptor antagonist hydroxyzine, is used to treat chronic idiopathic urticaria, perennial allergic rhinitis, seasonal allergic rhinitis, allergic asthma, physical urticaria, and atopic dermatitis. |
| Mechanism of Action: |
Cetirizine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The low incidence of sedation can be attributed to reduced penetration of cetirizine into the CNS as a result of the less lipophilic carboxyl group on the ethylamine side cha...
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| Absorption: | mean peak plasma concentration (Cmax) of 114 ng/mL at a time (Tmax) of 2.2 hours postdose was observed for cetirizine |
| Protein binding: | Very high (93%) plasma protein binding |
| Half Life: | 8.3 hours |
| Clearance: | 53 mL/min [healthy] |
| Toxicity: | Somnolence (sleepiness or unusual drowsiness), restlessness, irritability |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
