QuickView for chloral hydrate (compound)

Summary
General Info

PubChem

PubChem Compound 2707

Name:	Chloral Hydrate
PubChem Compound ID:	2707
Description:	A hypnotic and sedative used in the treatment of INSOMNIA.
Molecular formula:	C₂H₃Cl₃O₂
Molecular weight:	165.402 g/mol
Synonyms:	Lorinal; EINECS 206-117-5; CHEBI:28142; Dormal; Nycton; c0011; Ethanediol, 2,2,2-trichloro-; Amylofene; AI3-00082; ZINC03872049. show more » Lorinal; EINECS 206-117-5; CHEBI:28142; Dormal; Nycton; c0011; Ethanediol, 2,2,2-trichloro-; Amylofene; AI3-00082; ZINC03872049; Sontec; Felsules; Noctec (TN); Trichloracetaldehyd-hydrat [German]; Somni SED; Tosyl; Chloradorm; Nycoton; Chloral Hydrate; Chloral hydrate (JP15/USP); 1,1-Ethanediol, 2,2,2-trichloro-; 2,2, 2-Trichloro-1,1-ethanediol; Trichloracetaldehyd-hydrat; Chloraldural [Swiss]; Cohidrate; Aquachloral; Chloralex; 1,1,1-trichloro-2,2-dihydroxyethane; Caswell No. 168; Chloraldurat; Hynos; Phaldrone; HSDB 222; Somnos; Kessodrate; Bi 3411; Chloral monohydrate; C06899; Trichloroacetaldehyde monohydrate; Novochlorhydrate; Chloraldurat [German]; Chloralvan; DEA No. 2465; Escre; 302-17-0; NSC3210; EPA Pesticide Chemical Code 268100; Chloral hydrate [BAN:JAN]; sNplJqDJHtQdTaeUP@; Trawotox; Noctec; 2,2,2-trichloro-1,1-ethanediol; CCRIS 4142; SK-Chloral Hydrate; 4-01-00-03143 (Beilstein Handbook Reference); BRN 1698497; Trichloroacetaldehyde, hydrated; Hydral; Lycoral; Chloralhydrat; 109128-19-0; Chloralhydrate; trichloroacetaldehyde hydrate; D00265; Chlorali Hydras; 2,2,2-trichloroethane-1,1-diol; Hydrate de chloral; NSC 3210; 1,1,1-trichloro-2,2-ethanediol; Knockout drops; Rectules; Oradrate; Kloralhydrat; InChI=1/C2H3Cl3O2/c3-2(4,5)1(6)7/h1,6-7 show less «

DrugBank

Identification

Name:	Chloral Hydrate
Name (isomeric):	DB01563
Drug Type:	small molecule
Description:	A hypnotic and sedative used in the treatment of INSOMNIA.
Brand:	Somnote, Aquachloral Supprettes
Category:	Hypnotics and Sedatives
CAS number:	302-17-0

Pharmacology

Indication:	Mainly used as a hyponotic in the treatment of insomnia; however, it is only effective as a hypnotic for short-term use. May be used as a routine sedative preoperatively to decrease anxiety and cause sedation and/or sleep with respiration depression or cough reflex.
Absorption:	Rapidly absorbed in the GI tract following oral or rectal administration. Chloral hydrate and its active metabolite, trichloroethanol, have been detected in CSF, umbilical cord blood, fetal blood, and amniotic fluid.
Biotransformation:	Metabolized by the liver and erythrocytes to form trichloroethanol, an active metabolite. This reaction is catalyzed by alcohol dehydrogenase and other enzymes. Oxidation of chloral hydrate and trichloroethanol to trichloroacetic acid in the liver and kidneys also occurs to a lesser extent. Trichloroethanol also undergoes glucuronidation to produce an inactive metabolism.
Route of elimination:	Trichloroethanol, trichloroethanol glucuronide, and trichloroacetic acid are excreted in the urine. Some trichloroethanol glucuronide may be secreted into bile and excreted in the feces.

Interactions

Drug interaction:

Triprolidine

The CNS depressants, Triprolidine and Chloral hydrate, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.