Bookmark
Forward
QuickView for cholera toxin (compound)
PubChem Substance
| Name: | Cholera Toxin |
|---|---|
| PubChem Substance ID: | 167507 |
| Description: | An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells. |
| Synonyms: |
Cholera exotoxin; Exotoxin, vibrio cholerae; Toxins, cholera; 9012-63-9; Cholera entero-exotoxin; Choleragen; Cholera enterotoxin; Cholera toxin (Vibrio cholerae & Vibrio mimicus); CHOLERA TOXIN; Vibrio cholerae exotoxin.
show more » |
