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QuickView for cholic acid (compound)
PubChem
| Name: | Cholic Acid |
|---|---|
| PubChem Compound ID: | 221493 |
| Description: | A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. |
| Molecular formula: | C24H40O5 |
| Molecular weight: | 408.571 g/mol |
| Synonyms: |
Cholalic acid; Cholan-24-oic acid, 3,7,12-trihydroxy-, (3-alpha,5-beta,7-alpha,12-alpha)-; 3alpha,7alpha,12alpha-Trihydroxy-beta-cholanic acid; 5.beta.-Cholan-24-oic acid, 3.alpha.,7.alpha.,12.alpha.-trihydroxy-; Cholic acid (8CI); NSC-6135; 5beta-Cholanic acid, 3alpha,7alpha,12alpha-trihydroxy- (7CI); Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)-; 73163-53-8; AIDS017669.
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Cholalic acid; Cholan-24-oic acid, 3,7,12-trihydroxy-, (3-alpha,5-beta,7-alpha,12-alpha)-; 3alpha,7alpha,12alpha-Trihydroxy-beta-cholanic acid; 5.beta.-Cholan-24-oic acid, 3.alpha.,7.alpha.,12.alpha.-trihydroxy-; Cholic acid (8CI); NSC-6135; 5beta-Cholanic acid, 3alpha,7alpha,12alpha-trihydroxy- (7CI); Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)-; 73163-53-8; AIDS017669; 3-&alpha,7-&alpha,12-&alpha-trihydroxy-5-&beta-cholanate; Cholic acid; 3Alpha,7Alpha,12Alpha-trihydroxy-5Beta-cholan-24-oic acid; Cholan-24-oic acid, 3,7,12-trihydroxy-, (3.alpha.,5.beta.,7.alpha.,12.alpha.)-; LMST04010001; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid; 3alpha,7alpha,12alpha-Trihydroxycholanic acid; 3.alpha.,7.alpha., 12.alpha.-Trihydroxy-5.beta.-cholanic acid; 3,7,12-Trihydroxy-cholan-24-oic acid (3-alpha,5-beta,7-alpha,12-alpha); 3,7,12-Trihydroxycholanic acid; (3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxycholan-24-oic acid; 3,7,12-Trihydroxycholan-24-oic acid, (3alpha,5beta,7alpha,12alpha)-; 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanoic acid; Cholsaeure; cholate; (3.alpha.,5.beta.,7.alpha.,12.alpha.)-3,7,12-Trihydroxycholan-24-oic acid sodium salt; C00695; 17beta-[1-Methyl-3-carboxypropyl]etiocholane-3alpha,7alpha,12alpha-triol; Sodium Cholate; 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-cholan-24-oic acid; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate; Cholan-24-oic acid, 3,7,12-trihydroxy-, (3alpha,5beta,7alpha,12alpha)- (9CI); AIDS-017669; HSDB 982; NSC6135; 17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3alpha,7alpha,12alpha-triol; Cholic acid, 5beta-; 81-25-4; CHEBI:16359; Cholalin; 5beta-Cholanic acid-3alpha,7alpha,12alpha-triol 5beta-Cholic acid; 5beta-Cholan-24-oic acid, 3alpha,7alpha,12alpha-trihydroxy-; Colalin; CHD; Cholan-24-oic acid
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DrugBank
Identification
| Name: | Cholic Acid |
|---|---|
| Name (isomeric): | DB02659 |
| Drug Type: | small molecule |
| Description: | A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. |
| CAS number: | 81-25-4 |
Targets
Catalyzes the ferrous insertion into protoporphyrin IX
| UniProt ID: | P22830 | |||
|---|---|---|---|---|
| Gene: | FECH | |||
| Actions: | unknown | |||
| References: |
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| UniProt ID: | P00326 | |
|---|---|---|
| Gene: | ADH1C | |
| Actions: | unknown | |
| References: |
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Orphan receptor. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements
| UniProt ID: | P62508 | |
|---|---|---|
| Gene: | ESRRG | |
| Actions: | unknown | |
| References: |
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Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins
| UniProt ID: | P51161 | |
|---|---|---|
| Gene: | FABP6 | |
| Actions: | unknown | |
| References: |
|
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
| UniProt ID: | P13073 | |
|---|---|---|
| Gene: | COX4I1 | |
| Actions: | unknown | |
| References: |
|
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
| UniProt ID: | P00395 | |
|---|---|---|
| Gene: | MT-CO1 | |
| Actions: | unknown | |
| References: |
|
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1
| UniProt ID: | P00403 | |
|---|---|---|
| Gene: | MT-CO2 | |
| Actions: | unknown | |
| References: |
|
Subunits I, II and III form the functional core of the enzyme complex
| UniProt ID: | P00414 | |
|---|---|---|
| Gene: | MT-CO3 | |
| Actions: | unknown | |
| References: |
|
This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
| UniProt ID: | P20674 | |
|---|---|---|
| Gene: | COX5A | |
| Actions: | unknown | |
| References: |
|
| UniProt ID: | P10606 | |
|---|---|---|
| Gene: | COX5B | |
| Actions: | unknown | |
| References: |
|
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
| UniProt ID: | P09669 | |
|---|---|---|
| Gene: | COX6C | |
| Actions: | unknown | |
| References: |
|
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
| UniProt ID: | P24311 | |
|---|---|---|
| Gene: | COX7B | |
| Actions: | unknown | |
| References: |
|
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
| UniProt ID: | P15954 | |
|---|---|---|
| Gene: | COX7C | |
| Actions: | unknown | |
| References: |
|
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
| UniProt ID: | P10176 | |
|---|---|---|
| Gene: | COX8A | |
| Actions: | unknown | |
| References: |
|
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
| UniProt ID: | Q02221 | |
|---|---|---|
| Gene: | COX6A2 | |
| Actions: | unknown | |
| References: |
|
Connects the two COX monomers into the physiological dimeric form (By similarity)
| UniProt ID: | P14854 | |
|---|---|---|
| Gene: | COX6B1 | |
| Actions: | unknown | |
| References: |
|
This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport
| UniProt ID: | P24310 | |
|---|---|---|
| Gene: | COX7A1 | |
| Actions: | unknown | |
| References: |
|
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides
| UniProt ID: | P04054 | |
|---|---|---|
| Gene: | PLA2G1B | |
| Actions: | unknown | |
| References: |
|
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester
| UniProt ID: | P23141 | |
|---|---|---|
| Gene: | CES1 | |
| Actions: | unknown | |
| References: |
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Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
| UniProt ID: | Q7KZA3 | |
|---|---|---|
| Gene: | DKFZp686P18130 | |
| Actions: | unknown | |
| References: |
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The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut
| UniProt ID: | P54965 | |
|---|---|---|
| Gene: | cbh | |
| Actions: | unknown | |
| References: |
|
Transporters
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes
| UniProt ID: | O95342 | |||
|---|---|---|---|---|
| Gene: | ABCB11 | |||
| Actions: | substrate, inhibitor, inducer | |||
| References: |
|
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
| UniProt ID: | P08183 | |
|---|---|---|
| Gene: | ABCB1 | |
| Actions: | inducer | |
| References: |
|
May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Confers resistance to anticancer drugs. Transports LTC4. May protect milk against xenobiotics
| UniProt ID: | P33527 | |
|---|---|---|
| Gene: | ABCC1 | |
| Actions: | inducer | |
| References: |
|
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity)
| UniProt ID: | P46721 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene: | SLCO1A2 | ||||||||
| Actions: | substrate, inhibitor, inducer | ||||||||
| References: |
|
Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism
| UniProt ID: | Q12908 | |||||
|---|---|---|---|---|---|---|
| Gene: | SLC10A2 | |||||
| Actions: | substrate, inhibitor, inducer | |||||
| References: |
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Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter
| UniProt ID: | Q92887 | |
|---|---|---|
| Gene: | ABCC2 | |
| Actions: | inducer | |
| References: |
|
Mediates the Na(+)-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. May play an important role in the clearance of bile acids and organic anions from the liver
| UniProt ID: | Q9Y6L6 | |||
|---|---|---|---|---|
| Gene: | SLCO1B1 | |||
| Actions: | substrate, inhibitor, inducer | |||
| References: |
|
May act as an inducible transporter in the biliary and intestinal excretion of organic anions
| UniProt ID: | O15438 | |
|---|---|---|
| Gene: | ABCC3 | |
| Actions: | inhibitor | |
| References: |
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May be an organic anion pump relevant to cellular detoxification
| UniProt ID: | O15439 | ||
|---|---|---|---|
| Gene: | ABCC4 | ||
| Actions: | inhibitor | ||
| References: |
|
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium
| UniProt ID: | Q14973 | |||||
|---|---|---|---|---|---|---|
| Gene: | SLC10A1 | |||||
| Actions: | substrate, inhibitor | |||||
| References: |
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Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA)
| UniProt ID: | Q8TCC7 | ||
|---|---|---|---|
| Gene: | SLC22A8 | ||
| Actions: | inhibitor | ||
| References: |
|
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate
| UniProt ID: | Q9Y694 | |
|---|---|---|
| Gene: | SLC22A7 | |
| Actions: | inhibitor | |
| References: |
|
Mediates the Na(+)-independent transport of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP)
| UniProt ID: | Q9NPD5 | |
|---|---|---|
| Gene: | SLCO1B3 | |
| Actions: | substrate | |
| References: |
|
Carriers
Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport
| UniProt ID: | P07148 | |
|---|---|---|
| Gene: | FABP1 | |
| References: |
|
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