QuickView for ciliary neurotrophic factor (gene)

Gene Symbol:

CNTF Homo sapiens

Full name:

ciliary neurotrophic factor

Synonyms:

HCNTF, ciliary neurotrophic factor

Genomic Location:

Chr 11: 58146721-58149778

Description:

The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during i...

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The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  IRF1_01 ,  AP1_C ,  TGANTCA_AP1_C ,  TTANTCA_UNKNOWN ,  TCANNTGAY_SREBP1_01 ,  RYTTCCTG_ETS2_B ,  OCT1_04 ,  GATA3_01 ,  YTATTTTNR_MEF2_02 ,  SRF_Q6 ,  CATTGTYY_SOX9_B1 ,  E4BP4_01 ,  CTTTGA_LEF1_Q2 ,  CYTAGCAAY_UNKNOWN ,  MYB_Q5_01 ,  TTAYRTAA_E4BP4_01 ,  GATA1_04 ,  TGACCTY_ERR1_Q2 ,  TCF4_Q5 ,  WTGAAAT_UNKNOWN ,  OCT1_Q6 ,  RGAANNTTC_HSF1_01 ,  LEF1_Q2 ,  FOXO3_01 ,  HSF1_01 ,  PXR_Q2 ,  CREBP1_01 ,  AP1_Q2_01 ,  RAAGNYNNCTTY_UNKNOWN ,  HSF2_01 ,  OCT1_06 ,  RORA1_01 ,  MYB_Q6 ,  HLF_01 ,  TTGTTT_FOXO4_01 ,  GATA4_Q3 ,  AP1_Q2 ,  ER_Q6_02 ,  AACTTT_UNKNOWN ,  ERR1_Q2 ,  AP1_Q4_01 ,  TGACCTTG_SF1_Q6 ,  GGGNNTTTCC_NFKB_Q6_01 ,  GGGTGGRR_PAX4_03 ,  SF1_Q6 ,  MYB_Q3 ,  TCF11_01

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Cytogenetic Map:

11q12.1

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