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QuickView for cis-2 (gene)


Gene Symbol:
SOCS2 Homo sapiens Homo sapiens
Full name:
suppressor of cytokine signaling 2
Synonyms:
CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2, CIS-2, STAT-induced STAT inhibitor 2, cytokine-inducible SH2 protein 2
Genomic Location:
Chr 12: 92487729-92494109
Description:
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complex...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 12
12q22





GO Molecular Function

hormone receptor binding | kinase regulator activity | signaling receptor binding | cytokine receptor binding | molecular function regulator | signaling adaptor activity | JAK pathway signal transduction adaptor activity | protein binding, bridging | 1-phosphatidylinositol-3-kinase regulator activity | phosphatidylinositol 3-kinase regulator activity | growth hormone receptor binding | molecular adaptor activity | protein binding | SH3/SH2 adaptor activity | insulin-like growth factor receptor binding | enzyme regulator activity

GO Biological Process

negative regulation of cellular response to insulin stimulus | response to cytokine | regulation of neurogenesis | intracellular signal transduction | regulation of cell development | regulation of programmed cell death | phosphatidylinositol metabolic process | establishment of localization | response to hormone | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | JAK-STAT cascade | nervous system development | response to growth hormone | neurogenesis | interleukin-7-mediated signaling pathway | generation of neurons | phospholipid metabolic process | cellular process | secretion | localization | negative regulation of signaling | kinase regulator activity | negative regulation of developmental growth | response to estradiol | negative regulation of apoptotic process | regulation of multicellular organism growth | cellular response to growth hormone stimulus | response to peptide hormone | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | cellular response to organonitrogen compound | cellular lipid metabolic process | response to stimulus | response to peptide | protein modification process | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | molecular function regulator | response to nitrogen compound | cellular response to hormone stimulus | signaling adaptor activity | JAK pathway signal transduction adaptor activity | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of growth | multicellular organism development | cellular response to peptide hormone stimulus | phosphorus metabolic process | mammary gland development | regulation of catalytic activity | lipid metabolic process | regulation of phosphorylation | 1-phosphatidylinositol-3-kinase regulator activity | phosphatidylinositol 3-kinase regulator activity | mammary gland lobule development | regulation of neuron differentiation | response to lipid | cellular response to peptide | organophosphate metabolic process | protein modification by small protein conjugation | enzyme linked receptor protein signaling pathway | negative regulation of insulin receptor signaling pathway | cytokine-mediated signaling pathway | positive regulation of cell differentiation | cellular response to interleukin-7 | cellular response to cytokine stimulus | phosphorylation | negative regulation of multicellular organism growth | phosphate-containing compound metabolic process | lipid phosphorylation | regulation of lipid kinase activity | cell communication | regulation of cellular metabolic process | positive regulation of signal transduction | lipid modification | glycerolipid metabolic process | regulation of phospholipid metabolic process | protein metabolic process | regulation of growth | response to organic substance | gland development | protein ubiquitination | regulation of JAK-STAT cascade | lactation | regulation of kinase activity | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | regulation of body fluid levels | negative regulation of programmed cell death | body fluid secretion | organic substance metabolic process | animal organ development | regulation of insulin receptor signaling pathway | protein modification by small protein conjugation or removal | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | SH3/SH2 adaptor activity | mammary gland alveolus development | regulation of cell communication | negative regulation of signal transduction | signaling | response to organic cyclic compound | regulation of developmental growth | growth hormone receptor signaling pathway | cellular protein metabolic process | enzyme regulator activity | phosphatidylinositol phosphorylation | regulation of nervous system development | regulation of developmental process | glycerophospholipid metabolic process | developmental process | regulation of cell growth | cellular protein modification process | response to organonitrogen compound | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of neuron differentiation | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of signaling | post-translational protein modification | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

catalytic complex | phosphatidylinositol 3-kinase complex | extrinsic component of membrane | cell | cytoplasm | protein-containing complex | transferase complex | cytosol | intracellular | membrane