QuickView for cit (gene)
- Gene Symbol:
- CIT
Homo sapiens - Full name:
- citron rho-interacting serine/threonine kinase
- Synonyms:
- CITK, CRIK, MCPH17, STK21, citron Rho-interacting kinase, citron (rho-interacting, serine/threonine kinase 21), serine/threonine kinase 21, serine/threonine-protein kinase 21
- Genomic Location:
- Chr 12: 118607981-118799475
- Description:
-
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disord...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Gallus gallus , Pan troglodytes , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-128 , Predicted Gene Targets for miR-138 , Predicted Gene Targets for miR-148 , Predicted Gene Targets for miR-181 , Predicted Gene Targets for miR-221 , Predicted Gene Targets for miR-224 , Predicted Gene Targets for miR-25 , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-324-3p
- Cytogenetic Map:
-
12q24.23
GO Molecular Function
GTPase binding | Rho GTPase binding | cation binding | enzyme binding | ribonucleotide binding | SH3 domain binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | catalytic activity | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | scaffold protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | PDZ domain binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
mitotic cytokinesis | regulation of supramolecular fiber organization | regulation of cell cycle process | intracellular signal transduction | neuron death | cell differentiation | nervous system development | neurogenesis | regulation of organelle organization | regulation of actin polymerization or depolymerization | generation of neurons | cellular process | cytoskeleton-dependent cytokinesis | endomembrane system organization | regulation of cell cycle | positive regulation of cell division | positive regulation of cytokinesis | regulation of cellular process | cellular component organization | regulation of cell division | regulation of actin filament length | response to stimulus | protein serine/threonine kinase activity | programmed cell death | regulation of cellular component size | protein modification process | macromolecule modification | apoptotic process | system development | nitrogen compound metabolic process | regulation of actin cytoskeleton organization | multicellular organism development | phosphorus metabolic process | regulation of actin filament organization | positive regulation of cell cycle | cell cycle | neuron apoptotic process | cell division | G2/M transition of mitotic cell cycle | cytokinesis | phosphorylation | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cytokinesis | cell cycle G2/M phase transition | protein metabolic process | Golgi organization | anatomical structure development | mitotic cell cycle | metabolic process | protein kinase activity | organic substance metabolic process | cell death | signaling | cellular protein metabolic process | kinase activity | developmental process | organelle organization | positive regulation of cell cycle process | cellular protein modification process | cell cycle phase transition | regulation of actin filament-based process | cellular metabolic process | regulation of cellular component organization | regulation of cytoskeleton organization | signal transduction | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
cleavage furrow | Golgi stack | intracellular membrane-bounded organelle | somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | intracellular organelle | Golgi apparatus | Golgi cisterna | endomembrane system | plasma membrane | midbody | membrane-bounded organelle | organelle | cell division site | cell periphery | cytosol | intracellular | membrane
