QuickView for claudin 11 (gene)

Gene Symbol:

CLDN11 Homo sapiens

Full name:

claudin 11

Synonyms:

OSP, OTM, claudin-11, oligodendrocyte transmembrane protein, oligodendrocyte-specific protein

Genomic Location:

Chr 3: 171619359-171634581

Description:

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintain...

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This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SP1_Q4_01 ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  CTTTAAR_UNKNOWN ,  ZF5_B ,  ATGAAGG_MIR205 ,  SP1_Q2_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

3q26.2

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