QuickView for claudin 1 (gene)

Gene Symbol:

CLDN1 Homo sapiens

Full name:

claudin 1

Synonyms:

CLD1, ILVASC, SEMP1, claudin-1, senescence-associated epithelial membrane protein 1

Genomic Location:

Chr 3: 191506187-191522909

Description:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing ...

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Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TITF1_Q3 ,  ATTCTTT_MIR186 ,  GGGCGGR_SP1_Q6 ,  CTTTAAR_UNKNOWN ,  YRCCAKNNGNCGC_UNKNOWN ,  CDC5_01 ,  TGGTGCT_MIR29A_MIR29B_MIR29C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

3q28

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