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QuickView for clusterin (gene)


Gene Symbol:
CLU Homo sapiens Homo sapiens
Full name:
clusterin
Synonyms:
AAG4, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, clusterin, aging-associated protein 4, apolipoprotein J, complement cytolysis inhibitor, complement lysis inhibitor, complement-associated protein SP-40,40, ku70-binding protein 1, sulfated glycoprotein 2, testosterone-repressed prostate message 2
Genomic Location:
Chr 8: 27510368-27528244
Description:
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 8
8p21.1





GO Molecular Function

peptide binding | low-density lipoprotein particle receptor binding | amyloid-beta binding | enzyme binding | protein-containing complex binding | lipoprotein particle receptor binding | signaling receptor binding | hydrolase activity | ATPase activity | pyrophosphatase activity | catalytic activity | chaperone binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | nucleoside-triphosphatase activity | tau protein binding | amide binding | protein binding | misfolded protein binding | ubiquitin protein ligase binding | hydrolase activity, acting on acid anhydrides | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

GO Biological Process

positive regulation of immune response | negative regulation of amyloid-beta formation | regulation of supramolecular fiber organization | adaptive immune response | cell morphogenesis | glial cell proliferation | positive regulation of amyloid precursor protein catabolic process | response to virus | exocytosis | release of cytochrome c from mitochondria | positive regulation of cellular component organization | protein stabilization | protein localization to vacuole | regulation of localization | positive regulation of DNA-binding transcription factor activity | complement activation | lipid transport | regulation of programmed cell death | establishment of localization | negative regulation of protein homooligomerization | regulation of immune system process | regulation of nitric oxide biosynthetic process | platelet degranulation | negative regulation of cellular process | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | response to misfolded protein | defense response | nervous system development | negative regulation of mitochondrion organization | positive regulation of protein catabolic process | negative regulation of cellular response to thapsigargin | positive regulation of tau-protein kinase activity | neurogenesis | positive regulation of phosphate metabolic process | regulation of protein oligomerization | regulation of organelle organization | membrane organization | intracellular transport | microglial cell proliferation | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | secretion | organic substance catabolic process | localization | axon ensheathment | chaperone-mediated protein folding | protein transport | negative regulation of signaling | positive regulation of reactive oxygen species metabolic process | positive regulation of neurofibrillary tangle assembly | positive regulation of protein kinase activity | macromolecule localization | negative regulation of response to endoplasmic reticulum stress | negative regulation of apoptotic process | endomembrane system organization | regulation of proteolysis | positive regulation of catalytic activity | negative regulation of release of cytochrome c from mitochondria | positive regulation of nitrogen compound metabolic process | myelin maintenance | central nervous system myelination | establishment of localization in cell | negative regulation of cellular metabolic process | chaperone-mediated autophagy | negative regulation of apoptotic signaling pathway | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | gliogenesis | catabolic process | regulation of protein complex assembly | positive regulation of cellular protein metabolic process | response to topologically incorrect protein | cellular component organization | positive regulation of tumor necrosis factor production | positive regulation of cellular protein catabolic process | response to stimulus | lysosomal transport | protein targeting to lysosome | oligodendrocyte development | positive regulation of nitric oxide metabolic process | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | regulation of neuronal signal transduction | negative regulation of cellular response to tunicamycin | response to stress | intracellular protein transport | regulation of response to endoplasmic reticulum stress | vacuolar transport | ensheathment of neurons | axon ensheathment in central nervous system | regulation of humoral immune response | programmed cell death | positive regulation of proteolysis involved in cellular protein catabolic process | chaperone-mediated protein transport involved in chaperone-mediated autophagy | cellular localization | secretion by cell | organic hydroxy compound transport | positive regulation of proteolysis | negative regulation of protein oligomerization | cellular nitrogen compound metabolic process | apoptotic mitochondrial changes | negative regulation of metabolic process | cellular component assembly | regulation of protein processing | mitochondrion organization | negative regulation of amyloid precursor protein catabolic process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | protein targeting to vacuole | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | regulation of neurotransmitter levels | apoptotic process | positive regulation of reactive oxygen species biosynthetic process | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | regulation of protein stability | myelination | multicellular organism development | negative regulation of amyloid fibril formation | regulation of tau-protein kinase activity | leukocyte mediated immunity | regulation of catalytic activity | lipid metabolic process | regulation of phosphorylation | protein localization to lysosome | regulation of intrinsic apoptotic signaling pathway | plasma membrane organization | regulation of acute inflammatory response | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | regulation of gene expression | organic substance transport | protein catabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | peptide transport | positive regulation of protein complex assembly | cellular amide metabolic process | vesicle-mediated transport | protein localization to organelle | central nervous system myelin maintenance | cell proliferation | leukocyte proliferation | sterol transport | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | glial cell differentiation | regulated exocytosis | cellular protein-containing complex assembly | positive regulation of neuron death | cholesterol transport | protein activation cascade | regulation of apoptotic signaling pathway | microglial cell activation | regulation of complement activation | regulation of tumor necrosis factor production | regulation of amyloid precursor protein catabolic process | autophagy | protein import | regulation of mitochondrion organization | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | protein targeting to lysosome involved in chaperone-mediated autophagy | humoral immune response | regulation of protein metabolic process | regulation of protein phosphorylation | peptide metabolic process | reverse cholesterol transport | regulation of RNA metabolic process | positive regulation of transport | apoptotic signaling pathway | positive regulation of amyloid fibril formation | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | antimicrobial humoral response | protein-containing complex assembly | activation of immune response | regulation of protein homooligomerization | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | chaperone-mediated protein complex assembly | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | establishment of protein localization to organelle | anatomical structure development | complement activation, classical pathway | metabolic process | lipid localization | positive regulation of supramolecular fiber organization | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | regulation of amyloid fibril formation | regulation of proteasomal protein catabolic process | cellular protein localization | regulation of amyloid-beta clearance | oligodendrocyte differentiation | amide transport | regulation of vesicle-mediated transport | positive regulation of cell death | regulation of response to DNA damage stimulus | macrophage activation | immune response | negative regulation of protein complex assembly | positive regulation of cellular component biogenesis | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | protein folding | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | cell death | positive regulation of NF-kappaB transcription factor activity | positive regulation of kinase activity | regulation of phosphate metabolic process | establishment of protein localization to vacuole | establishment of protein localization | positive regulation of cytokine production | cell activation | regulation of reactive oxygen species biosynthetic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of cell communication | humoral immune response mediated by circulating immunoglobulin | negative regulation of signal transduction | transmembrane transport | signaling | regulation of transcription, DNA-templated | glial cell development | regulation of amyloid-beta formation | cell development | positive regulation of protein homooligomerization | regulation of endocytosis | protein localization | positive regulation of phosphorylation | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule localization | response to biotic stimulus | B cell mediated immunity | developmental process | organelle organization | regulation of inclusion body assembly | positive regulation of inclusion body assembly | regulation of transport | regulation of reactive oxygen species metabolic process | chaperone-mediated protein transport | positive regulation of protein oligomerization | innate immune response | protein targeting to vacuole involved in autophagy | negative regulation of supramolecular fiber organization | positive regulation of nitric oxide biosynthetic process | central nervous system development | protein transmembrane transport | positive regulation of metabolic process | protein targeting | immunoglobulin mediated immune response | immune system process | cellular metabolic process | positive regulation of amyloid-beta formation | regulation of cell death | negative regulation of cell death | regulation of inflammatory response | regulation of ubiquitin-dependent protein catabolic process | positive regulation of endocytosis | regulation of cellular component organization | response to other organism | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | chromaffin granule | dendrite | intracellular membrane-bounded organelle | neuron projection | extracellular matrix | somatodendritic compartment | organelle membrane | cytoplasmic vesicle | cell | spherical high-density lipoprotein particle | cytoplasmic vesicle lumen | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | lipoprotein particle | endoplasmic reticulum | dendritic tree | platelet alpha granule | inclusion body | Golgi apparatus | protein-containing complex | cell projection | secretory vesicle | endomembrane system | protein-lipid complex | vesicle | perinuclear region of cytoplasm | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | mitochondrial envelope | high-density lipoprotein particle | extracellular space | apical dendrite | cell periphery | membrane-enclosed lumen | plasma lipoprotein particle | secretory granule lumen | blood microparticle | mitochondrial membrane | cytosol | intracellular vesicle | cell surface | cytoskeleton | intracellular | neurofibrillary tangle | membrane | platelet alpha granule lumen | vesicle lumen