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QuickView for cosyntropin (compound)

Name: Cosyntropin
Name (isomeric): DB01284
Drug Type: biotech
Description: A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.
Brand: Synacthen depot, Cortrosyn
Category: Diagnostic Agents
CAS number: 16960-16-0
Indication: For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
Cosyntropin exhibits the full corticosteroidogenic activity of natural ACTH. Various studies have shown that the biologic activity of ACTH resides in the N- terminal portion of the molecule and that the 1-20 amino acid residue is the minimal sequence retaining full activity. Partial or complete loss of activity is noted with progressive shortening ...
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Mechanism of Action:
Cosyntropin combines with a specific receptor in the adrenal cell plasma membrane and, in patients with normal adrenocortical function, stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the qu...
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Absorption: Rapidly absorbed following intramuscular administration.
Half Life: About 15 minutes following intravenous administration.
Affected organisms: Humans and other mammals