QuickView for cpk (gene)

Gene Symbol:

PIK3C2A Homo sapiens

Full name:

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Synonyms:

CPK, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, C2-containing phosphatidylinositol kinase, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha, phosphoinositide 3-kinase-C2-alpha, phosphoinositide-3-kinase, class 2, alpha polypeptide, ptdIns-3-kinase C2 subunit alpha

Genomic Location:

Chr 11: 17064698-17147930

Description:

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain,...

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The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FOXO1_02 ,  RTAAACA_FREAC2_01 ,  PAX4_04 ,  FREAC7_01 ,  HNF3ALPHA_Q6 ,  FOX_Q2 ,  HFH3_01 ,  AAAYWAACM_HFH4_01 ,  FOXD3_01 ,  HFH1_01 ,  SRY_01 ,  HNF3_Q6 ,  HNF3B_01 ,  FOXJ2_01 ,  HFH4_01 ,  FREAC2_01 ,  POU3F2_02 ,  TTGTTT_FOXO4_01 ,  CEBP_C

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Cytogenetic Map:

11p15.1

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