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Description:: Aminopeptidase N2 (MEROPS identifier M01.030) is a membrane-bound insect peptidase found on the surface of midgut epithelial cells that acts as a receptor for an insecticidal crystal protein (ICP) from the insect pathogen Bacillus thuringiensis. Aminopeptidase N2 is attached to the membrane via a C-terminal glycosylphosphatidylinositol anchor. Binding of the ICP induces the epithelial cells to lyse colloidosmotically. In the moth Spodoptera exigua, the larvae of which feed on the leaves of a variety of crops, including asparagus, peas and beans, loss of one of the four aminopeptidase N-like genes resulted in resistance to infection. Bacillus thuringiensis is widely used to control crop insect pests, and development of resistance is a major agricultural problem.
Taxonomy/Path:: InterPro : Aminopeptidase N/Pld-like / Aminopeptidase N2

2 features

Symbol	EntrezGene ID
CG31233	42557
CG31343	326133