QuickView for cyclooxygenase 2 (gene)

Gene Symbol:

PTGS2 Homo sapiens

Full name:

prostaglandin-endoperoxide synthase 2

Synonyms:

COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2, prostaglandin G/H synthase 2, PGH synthase 2, PHS II, cyclooxygenase 2, cyclooxygenase 2b, prostaglandin H2 synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Genomic Location:

Chr 1: 184907592-184916179

Description:

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the indu...

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Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  GTACTGT_MIR101 ,  TACTTGA_MIR26A_MIR26B ,  HNF1_C ,  WTGAAAT_UNKNOWN ,  CDP_02 ,  AACTTT_UNKNOWN ,  NFKB_Q6 ,  NFKB_C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-26

Cytogenetic Map:

1q31.1

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