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QuickView for cyp2b6 (gene)


Gene Symbol:
CYP2B6 Homo sapiens Homo sapiens
Full name:
cytochrome P450 family 2 subfamily B member 6
Synonyms:
CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450, cytochrome P450 2B6, 1,4-cineole 2-exo-monooxygenase, cytochrome P450 IIB1, cytochrome P450, family 2, subfamily B, polypeptide 6, cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
Genomic Location:
Chr 19: 46189044-46216141
Description:
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The ...
Orthologs:
Mus musculus Rattus norvegicus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19q13.2


Transcripts Names
NM_000767
Protein Names
Q9UK46
P20813
Q2V565



GO Molecular Function

cofactor binding | cation binding | steroid hydroxylase activity | iron ion binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | ion binding | organic cyclic compound binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | arachidonic acid monooxygenase activity | tetrapyrrole binding | transition metal ion binding | heme binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | arachidonic acid epoxygenase activity

GO Biological Process

response to drug | cellular process | xenobiotic metabolic process | catabolic process | steroid hydroxylase activity | organic cyclic compound metabolic process | response to stimulus | cellular response to xenobiotic stimulus | drug catabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | lipid metabolic process | small molecule metabolic process | exogenous drug catabolic process | cellular ketone metabolic process | response to xenobiotic stimulus | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | arachidonic acid monooxygenase activity | drug metabolic process | metabolic process | oxidation-reduction process | organic substance metabolic process | steroid metabolic process | organic acid metabolic process | cellular metabolic process | oxidoreductase activity | arachidonic acid epoxygenase activity

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | membrane-bounded organelle | organelle | intracellular | membrane