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QuickView for dimercaprol (compound)


PubChem
Name: Dimercaprol
PubChem Compound ID: 3080
Description: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
Molecular formula: C3H8OS2
Molecular weight: 124.227 g/mol
Synonyms:
Panobal; Dimercaprolum [INN-Latin]; C02924; KBio1_000997; Dithioglycerol; Antoxol; 1,2-Dithioglycerol; 1, 2-Dimercapto-3-propanol; 59-52-9; BAL (TN).
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DrugBank
Identification
Name: Dimercaprol
Name (isomeric): DB06782
Drug Type: small molecule
Description: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
Synonyms:
2,3-Dimercaptopropanol; British Anti-Lewisite; BAL; 2,3-Dimercapro
Brand: Dimercaprol, Bal In Oil Injection
Category: Chelating Agents
CAS number: 59-52-9
Pharmacology
Indication: For the treatment of arsenic, gold and mercury poisoning. Indicated in acute lead poisoning when used concomitantly with edetate calcium disodium (DB00974).
Pharmacology:
Due to its oily nature, dimercaprol is not absorbed orally and its administration requires deep intra-muscular injection that is extremely painful and allergenic. It was found to mobilize and relocate lead to the brain, increasing its neurotoxic effects. Although treatment with dimercaprol increases the excretion of cadmium, there is a concomitant ...
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Mechanism of Action: The sulfhydryl groups of dimercaprol form complexes with certain heavy metals thus preventing or reversing the metallic binding of sulfhydryl-containing enzymes. The complex is excreted in the urine.
Absorption: After intra-muscular injection.
Route of elimination: Urine.
Half Life: The drug has a short half life.
Toxicity: The intramuscular LD50 in rats is approximately 105 mg/kg; intraperitoneally 140 mg/kg. The intraperitoneal LD80 in mice is approximately 125 mg/kg. Dimercaprol has been shown in animal experiments to increase brain deposition of arsenite, organic mercury compounds and increase the toxicity of cadmium and lead. Dimercaprol has been shown to induce seizure in animal studies and also is nephrotoxic.

Targets