Name: | dorzolamide |
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PubChem Compound ID: | 10520464 |
Molecular formula: | C10H16N2O4S3 |
Molecular weight: | 330.467 g/mol |
Name: | dorzolamide |
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Name (isomeric): | DB00869 |
Drug Type: | small molecule |
Brand: | Trusopt |
Brand name mixture: | Cosopt(Dorzolamide (Dorzolamide Hydrochloride) + Timolol (Timolol Maleate)) |
Category: | Carbonic Anhydrase Inhibitors, Antihypertensive Agents |
CAS number: | 120279-96-1 |
Indication: | For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Also used prophylatically for the inhibition of perioperative IOP increase (before neodynium yttrium aluminum garnet laser posterior capsulotomy). |
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Pharmacology: | Dorzolamide is topical CA inhibitor that is indicated for the reduction of elevated IOP in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. Dorzolamide reduces IOP by approximately 17-23% in patients with elevater IOP. |
Mechanism of Action: |
Dorzolamide is a sulfonamide and a highly specific carbonic anhydrase II (CA-II) inhibitor, which is the main CA isoenzyme involved in aqueous humor secretion. Inhibition of CA-II in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and flu...
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Protein binding: | ~33% |
Route of elimination: | Dorzolamide is primarily excreted unchanged in the urine; the metabolite also is excreted in urine. |
Half Life: | 4 months |
Toxicity: | Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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