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QuickView for eGFR (gene)


Gene Symbol:
EGFR Homo sapiens Homo sapiens
Full name:
epidermal growth factor receptor
Synonyms:
ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, epidermal growth factor receptor tyrosine kinase domain, erb-b2 receptor tyrosine kinase 1, proto-oncogene c-ErbB-1, receptor tyrosine-protein kinase erbB-1
Genomic Location:
Chr 7: 55054219-55242525
Description:
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autopho...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 7
7p11.2





GO Molecular Function

actin binding | guanyl-nucleotide exchange factor activity | kinase binding | transmembrane receptor protein tyrosine kinase activity | actin filament binding | GTPase binding | epidermal growth factor-activated receptor activity | cadherin binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | growth factor binding | molecular function regulator | catalytic activity | chromatin binding | ATP binding | ubiquitin-like protein ligase binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | MAP kinase kinase kinase activity | DNA binding | signaling receptor activity | purine nucleotide binding | phosphatidylinositol 3-kinase activity | identical protein binding | protein heterodimerization activity | ion binding | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | hormone binding | purine ribonucleoside triphosphate binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein tyrosine kinase activity | protein binding | double-stranded DNA binding | protein phosphatase binding | ubiquitin protein ligase binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | nitric-oxide synthase regulator activity | Ras guanyl-nucleotide exchange factor activity | protein kinase activity | virus receptor activity | transferase activity | small GTPase binding | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | kinase activity | calmodulin binding | phosphatase binding | epidermal growth factor binding | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of cyclin-dependent protein serine/threonine kinase activity | positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | regulation of ERK1 and ERK2 cascade | brain development | molting cycle | regulation of blood vessel diameter | response to radiation | cell morphogenesis | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | positive regulation of blood circulation | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | guanyl-nucleotide exchange factor activity | cell motility | neuron projection morphogenesis | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | regulation of localization | regulation of cell cycle G1/S phase transition | morphogenesis of an epithelium | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | eye development | phosphatidylinositol metabolic process | establishment of localization | response to hormone | response to hydroxyisoflavone | astrocyte development | negative regulation of cellular process | regulation of MAP kinase activity | response to dexamethasone | response to metal ion | regulation of protein localization to membrane | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of fibroblast proliferation | respiratory tube development | nervous system development | response to drug | reactive oxygen species metabolic process | cell part morphogenesis | regulation of G1/S transition of mitotic cell cycle | neurogenesis | positive regulation of phosphate metabolic process | regulation of DNA replication | peptidyl-tyrosine phosphorylation | positive regulation of cellular component movement | regulation of peptide hormone secretion | generation of neurons | positive regulation of protein secretion | membrane organization | salivary gland morphogenesis | phospholipid metabolic process | regulation of DNA repair | epidermal growth factor-activated receptor activity | regulation of bone remodeling | positive regulation of cellular biosynthetic process | cellular process | regulation of production of miRNAs involved in gene silencing by miRNA | regulation of cell motility | localization | cell projection morphogenesis | positive regulation of synaptic transmission | forebrain cell migration | negative regulation of signaling | positive regulation of peptidyl-serine phosphorylation | neuron development | positive regulation of reactive oxygen species metabolic process | reproductive system development | response to estradiol | multicellular organismal reproductive process | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | digestive tract morphogenesis | magnesium ion homeostasis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | regulation of canonical Wnt signaling pathway | activation of phospholipase C activity | tissue development | regulation of cell differentiation | interspecies interaction between organisms | positive regulation of vasoconstriction | response to cobalamin | regeneration | regulation of protein kinase B signaling | peptidyl-tyrosine autophosphorylation | regulation of cellular process | positive regulation of cell growth | negative regulation of cardiocyte differentiation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | hepaticobiliary system development | positive regulation of cyclin-dependent protein kinase activity | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | regulation of gene silencing by miRNA | negative regulation of epidermal growth factor receptor signaling pathway | cellular component organization | positive regulation of response to DNA damage stimulus | entry into host cell | cellular lipid metabolic process | MAPK cascade | viral life cycle | cellular response to metal ion | response to UV | head development | regulation of peptide secretion | response to stimulus | positive regulation of NIK/NF-kappaB signaling | peptide biosynthetic process | regulation of cellular protein localization | cellular response to mechanical stimulus | midgut development | respiratory system development | regulation of mitotic cell cycle phase transition | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | activation of phospholipase A2 activity | regulation of blood vessel size | cellular response to xenobiotic stimulus | gland morphogenesis | response to stress | positive regulation of nitric oxide mediated signal transduction | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | ovulation cycle | tube morphogenesis | regulation of blood circulation | regulation of cell cycle phase transition | circadian rhythm | telencephalon cell migration | positive regulation of protein kinase C activity | protein serine/threonine kinase activity | activation of phospholipase A2 activity by calcium-mediated signaling | reproduction | cellular response to inorganic substance | cellular localization | positive regulation of superoxide anion generation | rhythmic process | cellular response to cadmium ion | regulation of gene silencing | cellular nitrogen compound metabolic process | positive regulation of lipase activity | positive regulation of hormone secretion | cellular response to organic cyclic compound | ERBB signaling pathway | regulation of protein transport | blood circulation | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cofactor metabolic process | protein modification process | regulation of peptide transport | modulation of chemical synaptic transmission | cellular biosynthetic process | positive regulation of synaptic transmission, glutamatergic | embryo development | macromolecule modification | positive regulation of prolactin secretion | activation of protein kinase activity | positive regulation of production of miRNAs involved in gene silencing by miRNA | molecular function regulator | ERBB2 signaling pathway | metal ion homeostasis | embryonic placenta development | response to phenylpropanoid | tongue development | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of cellular response to stress | locomotion | positive regulation of phospholipase C activity | response to nitrogen compound | cellular response to hormone stimulus | response to light stimulus | regulation of superoxide metabolic process | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | astrocyte activation | multicellular organism development | cell migration | antibiotic metabolic process | regulation of synaptic transmission, glutamatergic | response to UV-A | positive regulation of DNA replication | regulation of MAPK cascade | phosphorus metabolic process | response to amino acid | positive regulation of inflammatory response | learning or memory | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | cellular response to oxidative stress | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | wound healing | regulation of nitric-oxide synthase activity | telencephalon development | positive regulation of cell cycle | positive regulation of protein localization to plasma membrane | regulation of gene expression | viral entry into host cell | protein localization to membrane | positive regulation of secretion | response to ketone | cellular response to stress | response to lipid | nervous system process | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | eyelid development in camera-type eye | animal organ morphogenesis | MAP kinase kinase kinase activity | liver development | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of Notch signaling pathway | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | response to corticosteroid | cellular amide metabolic process | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to nutrient | phosphatidylinositol 3-kinase activity | morphogenesis of an epithelial fold | response to oxidative stress | positive regulation of hydrolase activity | translation | second-messenger-mediated signaling | positive regulation of phospholipase A2 activity | cognition | positive regulation of cell migration | cell proliferation | biosynthetic process | response to cadmium ion | response to osmotic stress | regulation of cellular protein metabolic process | glial cell differentiation | cellular response to glucocorticoid stimulus | protein insertion into membrane | phosphorylation | digestive tract development | regulation of phospholipase activity | epidermis development | skin development | cerebral cortex cell migration | response to xenobiotic stimulus | cellular response to amino acid stimulus | protein phosphorylation | cation homeostasis | cellular response to corticosteroid stimulus | phosphate-containing compound metabolic process | sensory organ development | cellular response to drug | lipid phosphorylation | chordate embryonic development | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | liver regeneration | positive regulation of protein localization to membrane | astrocyte differentiation | activation of MAPKK activity | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | lipid modification | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | peptide metabolic process | regulation of locomotion | embryo development ending in birth or egg hatching | glycerolipid metabolic process | regulation of RNA metabolic process | regulation of tube size | positive regulation of transport | viral process | positive regulation of peptide hormone secretion | cerebral cortex development | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | regulation of mitotic cell cycle | drug metabolic process | protein tyrosine kinase activity | regulation of phospholipase C activity | positive regulation of molecular function | calcium-mediated signaling | cellular response to epidermal growth factor stimulus | establishment of protein localization to membrane | neuron differentiation | multicellular organism reproduction | protein metabolic process | regulation of fibroblast proliferation | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | hair cycle | response to organic substance | gland development | tissue morphogenesis | digestive system development | regulation of kinase activity | response to wounding | response to antineoplastic agent | response to mechanical stimulus | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | regulation of vasoconstriction | cell projection organization | metabolic process | regulation of protein catabolic process | regulation of protein localization to plasma membrane | regulation of RNA biosynthetic process | negative regulation of programmed cell death | embryonic organ development | negative regulation of mitotic cell cycle | regulation of tube diameter | cellular protein localization | regulation of bone resorption | regulation of tissue remodeling | nitric-oxide synthase regulator activity | hair cycle process | chemical homeostasis | Ras guanyl-nucleotide exchange factor activity | regulation of secretion | behavior | cell adhesion | regulation of gene silencing by RNA | regulation of response to DNA damage stimulus | negative regulation of ERBB signaling pathway | protein kinase activity | cellular response to reactive oxygen species | neuron projection development | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | virus receptor activity | response to vitamin | animal organ development | response to reactive oxygen species | forebrain development | pallium development | gene expression | amide biosynthetic process | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | diterpenoid metabolic process | positive regulation of kinase activity | ion homeostasis | skin epidermis development | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | cellular response to steroid hormone stimulus | establishment of protein localization | cell-cell adhesion | regulation of JNK cascade | positive regulation of phospholipase activity | cell activation | positive regulation of MAPK cascade | lung development | cellular response to dexamethasone stimulus | response to epidermal growth factor | positive regulation of protein transport | camera-type eye development | positive regulation of canonical Wnt signaling pathway | regulation of peptidyl-serine phosphorylation | negative regulation of cell cycle | negative regulation of protein catabolic process | negative regulation of protein metabolic process | cellular response to estradiol stimulus | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | glial cell development | response to organic cyclic compound | cell development | regulation of ERBB signaling pathway | protein localization | regulation of epithelial cell proliferation | regulation of production of small RNA involved in gene silencing by RNA | positive regulation of phosphorylation | regulation of phospholipase A2 activity | cellular protein metabolic process | enzyme regulator activity | phosphatidylinositol phosphorylation | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | positive regulation of tissue remodeling | reproductive structure development | positive regulation of gene silencing by miRNA | isoprenoid metabolic process | regulation of developmental process | glycerophospholipid metabolic process | positive regulation of DNA metabolic process | kinase activity | developmental process | regulation of cell growth | cellular protein modification process | tube development | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | regulation of superoxide anion generation | positive regulation of bone resorption | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | response to calcium ion | central nervous system development | hydrogen peroxide metabolic process | transmembrane receptor protein tyrosine kinase signaling pathway | in utero embryonic development | positive regulation of metabolic process | ossification | regulation of nitric oxide mediated signal transduction | positive regulation of Wnt signaling pathway | negative regulation of Notch signaling pathway | cellular metabolic process | placenta development | cellular response to organic substance | regulation of protein localization | exocrine system development | regulation of cell death | regulation of smooth muscle cell proliferation | positive regulation of cell motility | salivary gland development | response to steroid hormone | negative regulation of cell death | positive regulation of blood vessel diameter | regulation of inflammatory response | divalent inorganic cation homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | hair follicle development | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | animal organ regeneration | positive regulation of gene expression | response to glucocorticoid | positive regulation of DNA repair | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

clathrin coat of endocytic vesicle | integral component of membrane | basal plasma membrane | intracellular membrane-bounded organelle | early endosome membrane | synapse | late endosome | apical plasma membrane | clathrin-coated endocytic vesicle membrane | endocytic vesicle membrane | clathrin-coated vesicle membrane | adherens junction | organelle membrane | vesicle coat | clathrin-coated vesicle | nuclear membrane | clathrin coat of coated pit | focal adhesion | cytoplasmic vesicle | basal part of cell | cell | multivesicular body | plasma membrane protein complex | multivesicular body, internal vesicle | Shc-EGFR complex | intrinsic component of membrane | AP-2 adaptor complex | cytoplasm | clathrin-coated endocytic vesicle | cell-substrate junction | intracellular organelle | receptor complex | endoplasmic reticulum | membrane microdomain | apical part of cell | AP-type membrane coat adaptor complex | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | clathrin adaptor complex | endomembrane system | endoplasmic reticulum membrane | plasma membrane | nuclear envelope | membrane raft | vesicle | perinuclear region of cytoplasm | clathrin-coated pit | integral component of plasma membrane | Golgi membrane | endosome | extracellular region | coated vesicle membrane | membrane-bounded organelle | clathrin coat | nucleus | organelle | vesicle membrane | extracellular space | cell periphery | clathrin vesicle coat | membrane-enclosed lumen | early endosome | basolateral plasma membrane | cell-substrate adherens junction | multivesicular body, internal vesicle lumen | intracellular vesicle | cell surface | endocytic vesicle | intracellular | cell junction | membrane | vesicle lumen | cytoplasmic vesicle membrane | intrinsic component of plasma membrane | membrane coat | coated vesicle