QuickView for eIF4E (gene)

Gene Symbol:

EIF4E Homo sapiens

Full name:

eukaryotic translation initiation factor 4E

Synonyms:

AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E, eukaryotic translation initiation factor 4E, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E-like 1, mRNA cap-binding protein

Genomic Location:

Chr 4: 100020235-100070139

Description:

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the r...

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The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  GATTGGY_NFY_Q6_01 ,  ARNT_01 ,  P53_DECAMER_Q2 ,  VDR_Q3 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  CATTGTYY_SOX9_B1 ,  ATTACAT_MIR3803P ,  GAGACTG_MIR452 ,  MAX_01 ,  TGTGTGA_MIR377 ,  YATTNATC_UNKNOWN ,  VDR_Q6 ,  STAT6_01 ,  AP1_Q6 ,  CTTTGA_LEF1_Q2 ,  TTF1_Q6 ,  GGTGAAG_MIR412 ,  TGACCTY_ERR1_Q2 ,  TCF4_Q5 ,  CTTTGTA_MIR524 ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  STAT3_02 ,  CACCCBINDINGFACTOR_Q6 ,  ACATTCC_MIR1_MIR206 ,  TTGGGAG_MIR150 ,  CATTTCA_MIR203 ,  YYCATTCAWW_UNKNOWN ,  AP4_01 ,  BACH2_01 ,  ATTCTTT_MIR186 ,  MYCMAX_01 ,  ACCAAAG_MIR9 ,  USF_C ,  AP1_Q2_01 ,  NKX25_02 ,  SPZ1_01 ,  HFH4_01 ,  POU1F1_Q6 ,  USF_01 ,  AP1_Q4 ,  OCT1_06 ,  STAT_01 ,  BACH1_01 ,  USF_Q6_01 ,  PAX5_01 ,  TGCTTTG_MIR330 ,  T3R_Q6 ,  TTCYNRGAA_STAT5B_01 ,  TGACAGNY_MEIS1_01 ,  STAT5A_01 ,  ER_Q6_01 ,  SMAD_Q6 ,  AACTTT_UNKNOWN ,  USF_02 ,  CACTTTG_MIR520G_MIR520H ,  GGGTGGRR_PAX4_03 ,  TGASTMAGC_NFE2_01 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-203 ,  Predicted Gene Targets for miR-376c ,  Predicted Gene Targets for miR-493-5p

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Cytogenetic Map:

4q23

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