QuickView for eda (gene)

Gene Symbol:

EDA Homo sapiens

Full name:

ectodysplasin A

Synonyms:

ECTD1, ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, TNLG7C, XHED, XLHED, ectodysplasin-A, X-linked anhidroitic ectodermal dysplasia protein, oligodontia 1, tumor necrosis factor ligand 7C

Genomic Location:

Chr X: 68752636-69176047

Description:

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dy...

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The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  SP1_01 ,  IRF1_01 ,  ACAACTT_MIR382 ,  GAGCCTG_MIR484 ,  TGGNNNNNNKCCAR_UNKNOWN ,  GATA_Q6 ,  YATGNWAAT_OCT_C ,  GATA_C ,  SMAD3_Q6 ,  GCANCTGNY_MYOD_Q6 ,  AP2GAMMA_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTTTGA_LEF1_Q2 ,  OCT1_Q5_01 ,  GATA1_04 ,  COMP1_01 ,  GTGTGAG_MIR342 ,  SOX9_B1 ,  LEF1_Q6 ,  PAX4_02 ,  CACCCBINDINGFACTOR_Q6 ,  PAX2_01 ,  TTGGGAG_MIR150 ,  NFY_Q6_01 ,  CAGNYGKNAAA_UNKNOWN ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  RRAGTTGT_UNKNOWN ,  CCAWYNNGAAR_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  GATA6_01 ,  NKX61_01 ,  NKX25_02 ,  TGTTTGY_HNF3_Q6 ,  GGCAGCT_MIR22 ,  AP2_Q6 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  AFP1_Q6 ,  STAT5A_04 ,  GAGCCAG_MIR149 ,  YTAATTAA_LHX3_01 ,  CTGAGCC_MIR24 ,  CTGCAGY_UNKNOWN ,  CCCNNNNNNAAGWT_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CDC5_01 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  YNGTTNNNATT_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TCF1P_Q6 ,  CP2_01 ,  GGGTGGRR_PAX4_03 ,  LMO2COM_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-324-5p ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-149

Cytogenetic Map:

Xq13.1

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