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QuickView for eicosapentaenoic acid (compound)


PubChem
Name: Eicosapentaenoic Acid
PubChem Compound ID: 3209
Description: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Molecular formula: C20H30O2
Molecular weight: 302.451 g/mol
Synonyms:
Bio1_000719; KBio2_002616; Bio1_001208; Bio2_000528; CBiol_001944; KBio2_000048; Bio2_000048; KBioGR_000048; KBio3_000095; KBio3_000096.
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DrugBank
Identification
Name: Eicosapentaenoic Acid
Name (isomeric): DB00159
Drug Type: small molecule
Description: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Synonyms:
Timnodonic acid; Icosapentaenoic acid; EPA; Eicosapentaenoic acid
Category: Micronutrient, Dietary supplement
CAS number: 10417-94-4
Pharmacology
Indication: EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.
Pharmacology:
Eicosanoids are chemical messengers derived from 20-carbon polyunsaturated fatty acids that play critical roles in immune and inflammatory responses. Both 20-carbon omega-6 fatty acids (arachidonic acid) and 20-carbon omega-3 fatty acids (EPA) can be found in cell membranes. During an inflammatory response, arachidonic acid and EPA are metabolized ...
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Mechanism of Action:
The anti-inflammatory, antithrombotic and immunomodulatory actions of EPA is probably due to its role in eicosanoid physiology and biochemistry. Most eicosanoids are produced by the metabolism of omega-3 fatty acids, specifically, arachidonic acid. These eicosanoids, leukotriene B4 (LTB4) and thromboxane A2 (TXA2) stimulate leukocyte chemotaxis, pl...
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Affected organisms: Humans and other mammals

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Carriers