QuickView for endostatin (gene)

Gene Symbol:

COL18A1 Homo sapiens

Full name:

collagen type XVIII alpha 1 chain

Synonyms:

KNO, KNO1, KS, collagen alpha-1(XVIII) chain, antiangiogenic agent, collagen alpha-1(XVIII) chain isoform 1 preproprotein, collagen, type XVIII, alpha 1, endostatin, multi-functional protein MFP

Genomic Location:

Chr 21: 45649525-45758062

Description:

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled rec...

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This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_01 ,  CTTTGA_LEF1_Q2 ,  TCF4_Q5 ,  GGGAGGRR_MAZ_Q6 ,  LEF1_Q6 ,  CAGGTG_E12_Q6 ,  CCCNNGGGAR_OLF1_01 ,  TCF1P_Q6 ,  ACCTGTTG_UNKNOWN ,  AGGAAGC_MIR5163P

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-9

Cytogenetic Map:

21q22.3

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