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QuickView for enprofylline (compound)

Name: enprofylline
PubChem Compound ID: 1676
Molecular formula: C8H10N4O2
Molecular weight: 194.191 g/mol
Enprofylline [USAN:INN]; EU-0100910; Lopac-P-5679; D04006; Enprofilina [INN-Spanish]; EINECS 255-201-8; 3-PROPYLXANTHINE; Enprofylline (USAN); Nilyph; 41078-02-8.
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Name: enprofylline
Name (isomeric): DB00824
Drug Type: small molecule
3-Propylxanthine; Enprofyllinum [INN-Latin]; 3-n-Propylxanthine; Enprofilina [INN-Spanish]
Brand: Oxeze, Nilyph
Category: Antiarrhythmic Agents, Anti-Asthmatic Agents, Bronchodilator Agents
CAS number: 41078-02-8
Indication: Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Pharmacology: Enprofylline is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine. It antagonizes erythrocyte phosphodiesterase, increasing cAMP activity.
Mechanism of Action: Enprofylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, enprofylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
Absorption: Rapidly absorbed from the digestive tract
Protein binding: 49%
Half Life: 1.9 hours
Affected organisms: Humans and other mammals