Name: | Ephedrine |
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PubChem Compound ID: | 11972440 |
Description: | A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. |
Molecular formula: | C10H15NO |
Molecular weight: | 165.232 g/mol |
Synonyms: |
D-Pseudoephedrine
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Name: | Ephedrine |
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Name (isomeric): | DB01364 |
Drug Type: | small molecule |
Description: | A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists. |
Category: | Adrenergic Agents, Sympathomimetics, Vasoconstrictor Agents, Central Nervous System Stimulants |
CAS number: | 299-42-3 |
Indication: | Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia. |
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Pharmacology: | Ephedrine is similar in structure to the derivatives amphetamine and methamphetamine. Chemically, it is an alkaloid derived from various plants in the genus Ephedra (family Ephedraceae). It works mainly by increasing the activity of noradrenaline on adrenergic receptors. |
Mechanism of Action: |
Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic α-receptors and β-receptors, b...
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Absorption: | 85% |
Route of elimination: | mainly renal |
Half Life: | 3-6 hours |
Toxicity: | Cardiovascular: tachycardia, cardiac arrhythmias, angina pectoris, vasoconstriction with hypertension |
Drug interaction: |
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