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PubChem
| Name: | Estrone |
|---|---|
| PubChem Compound ID: | 10401044 |
| Description: | An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. |
| Molecular formula: | C18H22O2 |
| Molecular weight: | 272.374 g/mol |
DrugBank
Identification
| Name: | Estrone |
|---|---|
| Name (isomeric): | DB00655 |
| Drug Type: | small molecule |
| Description: | An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women. |
| Brand: | Femestrone Injection, Hiestrone, Estrona [INN-Spanish], Estrin, Oestroform, Hormovarine, OVEX, Follestrine, Oestronum, Thelykinin, GSS 33, Ketohydroxyoestrin, Unden, Ketodestrin, Ovifollin, Oestrone, Estrusol, Ketohydroxy-Estratriene, Fermidyn, Folliculin, Ketophydroxyestrin, Hormestrin, Glandubolin, Aquacrine, Estrona, Kestrone, Folikrin, Folisan, Follicular Hormone, Tokokin, Menformon A, Follidrin, Sinafid M-48, Follicunodis, Esterone, Folliculine Benzoate, Ketohydroxyestrin, Estrona [Spanish], Oestrone [Steroidal Oestrogens], Estrone-A, Folliculine, Kolpon, Estronum [INN-Latin], Oestrin, Follestrol, Menformon, Disynformon, Hormofollin, Femidyn, Femestrone Inj., Cristallovar, Solliculin, Mestronaq, Theelin, Thynestron, Estrogenic Substance, Wynestron, Crystogen, Estron, Estrol, Destrone, Folipex, Crinovaryl, Thelestrin, Wynestronpencap M, Perlatan, Penncap M, Menagen, Endofolliculina, Estrugenone, Estrone [Usan:Inn], Oestroperos, Estrovarin |
| Brand name mixture: | Cimicifuga Plex(Caulophyllum Thalictroides + Cimicifuga Racemosa + Copper + Cotton Plant + Estrone + Histamine Dihydrochloride + Hypothalamus + Magnesium Phosphate Dibasic + Pituitary Whole + Platinum + Sepia Officinalis L + Thyroid), Holis 98(Dioscorea Vilosa + Estrone + Salvia + Saw Palmetto) |
| Category: | Estrogens, Osteoporosis Prophylactic, Antineoplastic Agents, Anti-menopausal Agents |
| CAS number: | 53-16-7 |
Pharmacology
| Indication: | For management of perimenopausal and postmenopausal symptoms. |
|---|---|
| Pharmacology: |
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. The ...
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| Mechanism of Action: |
Estrogens enter the cells of responsive tissues (e.g. female organs, breasts, hypothalamus, pituitary) where they interact with estrogen receptors. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes. Estr...
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| Absorption: | 43% |
| Protein binding: | > 95% |
| Biotransformation: | Hepatic. |
| Half Life: | 19 hours |
| Toxicity: | Symptoms of overdose include nausea and vomiting. Estrogen related side effects include nausea, breast tenderness, fluid retention and edema, headaches and/or migraines, chloasma and poor contact lens fit. Estrogen hormone deficiency is associated with breakthrough bleeding, hypomenorrhea, irritability, depression and menopausal symptoms. Withdrawal bleeds may occur in females. |
| Affected organisms: | Humans and other mammals |
Interactions
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