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QuickView for etanercept (compound)

Name: etanercept
Name (isomeric): DB00005
Drug Type: biotech
Tumor necrosis factor receptor 2; TNF-R2; p80 TNF-alpha receptor; Tumor necrosis factor receptor type II; Tumor necrosis factor receptor superfamily member 1B precursor; CD120b; p75
Brand: Enbrel, Enbrel Sureclick, Enbrel (Immunex Corp)
Category: Immunomodulatory Agents, Antirheumatic Agents
CAS number: 185243-69-0
Indication: For treatment of severe active rheumatoid arthritis in adults, severe juvenile idiopathic arthritis, ankylosing spondylitis, and severe plaque psoriasis.
Tumor necrosis factor TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in tissues and fluids of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Etanercept binds specifically to tumor necrosis factor (TNF) a...
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Mechanism of Action:
There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them f...
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Half Life: 102 +/- 30 hrs
Clearance: 160 +/- 80 mL/hr [RA patients]
Affected organisms: Humans and other mammals
Drug interaction:
TrastuzumabTrastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.