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PubChem Substance
| Name: | Ethiodized Oil |
|---|---|
| PubChem Substance ID: | 167250 |
| Description: | Ethyl ester of iodinated fatty acid of poppyseed oil. It contains 37% organically bound iodine and has been used as a diagnostic aid (radiopaque medium) and as an antineoplastic agent when part of the iodine is 131-I. (From Merck Index, 11th ed) |
| Synonyms: |
EOE 13; Ethiodized oil (9CI); Ethiodol; ETHIODIZED OIL; Ethiodized Oil [USAN]; 8008-53-5
|
DrugBank
Identification
| Name: | Ethiodized Oil |
|---|---|
| Name (isomeric): | DB00965 |
| Drug Type: | small molecule |
| Description: | Ethyl ester of iodinated fatty acid of poppyseed oil. It contains 37% organically bound iodine and has been used as a diagnostic aid (radiopaque medium) and as an antineoplastic agent when part of the iodine is 131-I. (From Merck Index, 11th ed) |
| Synonyms: |
EOE 13
|
| Brand: | Ethiodol |
| Category: | Antineoplastic Agents, Contrast Media |
| CAS number: | 8008-53-5 |
Pharmacology
| Indication: | For use as a radio-opaque medium for hysterosalpingography and lymphography, and as an antineoplastic agent when part of the iodine is 131-I. It is also used in follow-up imaging for chemoembolization. |
|---|---|
| Pharmacology: |
There has been little detailed investigation of the metabolic fate of ethiodized oil in either man or animals. However, the fate of ethiodized oil following Iymphangiography in dogs has been reported. Koehler et al. employed I131-tagged ethiodol for lymphangiography in dogs and analyses of individual organs at various time interva...
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| Mechanism of Action: | Ethiodized oil is selectively retained in tumor vessels for long periods, and is used for imaging organs such as liver, lung, stomach, and thyroid. Labeled with I-131 or other beta emitters (Y-90 or P-32), ethiodized oil can deliver a high internal radiation dose to certain tumors with minimal effect on healthy tissues. |
| Route of elimination: | Urinary excretion in the form of inorganic iodine was revealed as the chief mode of iodine loss from the system. |
| Toxicity: | Intravenous LD50 in dog is 1580mg/kg. Symptoms of overdose include dyspnea and change in clotting factors. |
| Affected organisms: | Humans and other mammals |
