Name: | Ethosuximide |
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PubChem Compound ID: | 10630591 |
Description: | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. |
Molecular formula: | C7H11NO2 |
Molecular weight: | 141.168 g/mol |
Name: | Ethosuximide |
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Name (isomeric): | DB00593 |
Drug Type: | small molecule |
Description: | An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. |
Synonyms: |
Ethosuccinimide; Etosuximida; Ethosuccimide; Aethosuximide; Ethosuxide
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Brand: | Atysmal, Ronton, Suximal, Zartalin, Simatin, Piknolepsin, Petnidan, Thetamid, Peptinimid, Succimal, Zarodan, Mesentol, Ethymal, Petinimid, Etomal, Epileo Petit Mal, Pyknolepsinum, Thilopemal, Asamid, Pentinimid, Suxinutin, Pemalin, Zarontin, Succimitin, Emeside, Suxin, Capitus, Zarondan, Pemal, Suxilep, Zaraondan |
Category: | Succinimides, Anticonvulsants |
CAS number: | 77-67-8 |
Indication: | For the treatment of petit mal epilepsy. |
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Pharmacology: |
Used in the treatment of epilepsy. Ethosuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central...
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Mechanism of Action: |
Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The i...
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Absorption: | Bioavailability following oral administration is 93%. |
Biotransformation: | Hepatic, via CYP3A4 and CYP2E1. |
Half Life: | 53 hours |
Toxicity: | Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. |
Affected organisms: | Humans and other mammals |
Food interaction: |
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Drug interaction: |
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