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QuickView for ethoxyzolamide (compound)


PubChem
Name: Ethoxzolamide
PubChem Compound ID: 3295
Description: A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
Molecular formula: C9H10N2O3S2
Molecular weight: 258.319 g/mol
Synonyms:
452-35-7; 6-ethoxy-1,3-benzothiazole-2-sulfonamide; Glaucotensil; Ethoxazolamide; BRN 0212240; 2-Benzothiazolesulfonamide, 6-ethoxy-; U-4191; NSC 10679; SMR000059148; Etoxzolamide.
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DrugBank
Identification
Name: Ethoxzolamide
Name (isomeric): DB00311
Drug Type: small molecule
Description: A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
Synonyms:
6-Ethoxy-1,3-benzothiazole-2-sulfonamide; Ethoxyzolamide; Ethoxazolamide; Etoxzolamide
Brand: Redupresin, Glaucotensil, Diuretic C, Cardrase, Ethamide
Category: Carbonic Anhydrase Inhibitors, Diuretics
CAS number: 452-35-7
Pharmacology
Indication: For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy.
Pharmacology:
Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous...
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Mechanism of Action:
Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium syste...
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Absorption: Rapidly absorbed with 65% bioavailability
Protein binding: ~89%
Half Life: 2.5-5.5 hours
Affected organisms: Humans and other mammals

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