Name: | Ethoxzolamide |
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PubChem Compound ID: | 3295 |
Description: | A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia. |
Molecular formula: | C9H10N2O3S2 |
Molecular weight: | 258.319 g/mol |
Synonyms: |
452-35-7; 6-ethoxy-1,3-benzothiazole-2-sulfonamide; Glaucotensil; Ethoxazolamide; BRN 0212240; 2-Benzothiazolesulfonamide, 6-ethoxy-; U-4191; NSC 10679; SMR000059148; Etoxzolamide.
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Name: | Ethoxzolamide |
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Name (isomeric): | DB00311 |
Drug Type: | small molecule |
Description: | A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia. |
Synonyms: |
6-Ethoxy-1,3-benzothiazole-2-sulfonamide; Ethoxyzolamide; Ethoxazolamide; Etoxzolamide
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Brand: | Redupresin, Glaucotensil, Diuretic C, Cardrase, Ethamide |
Category: | Carbonic Anhydrase Inhibitors, Diuretics |
CAS number: | 452-35-7 |
Indication: | For use in the treatment of duodenal ulcers, as a diuretic, and in the treatment of glaucoma, and may also be useful in the treatment of seizures associated with epilepsy. |
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Pharmacology: |
Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous...
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Mechanism of Action: |
Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium syste...
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Absorption: | Rapidly absorbed with 65% bioavailability |
Protein binding: | ~89% |
Half Life: | 2.5-5.5 hours |
Affected organisms: | Humans and other mammals |