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Summary
General Info

PubChem

PubChem Compound 156397

PubChem Compound 156397

Name:	Edetic Acid
PubChem Compound ID:	156397
Description:	A chelating agent (CHELATING AGENTS) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Molecular formula:	C₃₀H₃₆Ca₄N₆Na₄O₂₄
Molecular weight:	1116.9 g/mol
Synonyms:	76353-66-7; 60-00-4; Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, calcium sodium salt; EDTA calcium sodium salt; N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine) calcium sodium salt

DrugBank

Identification

Name:	Edetic Acid
Name (isomeric):	DB00974
Drug Type:	small molecule
Description:	A chelating agent (CHELATING AGENTS) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Synonyms:	Calcium Disodium Versenate; Calcium disodium versenate (TN); Edetate Calcium; Calcium Disodium Edetate (JAN); EDT; CaEDTA; Edetate calcium disodium (USP); EDTA
Brand:	Endrate, Cheladrate, Versenate, Titriplex, Havidote
Category:	Anticoagulants, Food Additives, Chelating Agents
CAS number:	62-33-9

Pharmacology

Indication:	For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
Pharmacology:	Edetate calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the uri... show more » Edetate calcium is a heavy metal chelating agent. The calcium in edetate calcium can be displaced by divalent or trivalent metals to form a stable water soluble complex that can be excreted in the urine. In theory, 1 g of edetate calcium can theoretically bind 620 mg of lead, but in reality only about 5 mg per gram is actually excreted into the urine in lead poisoned patients. In addition to chelating lead, edetate calcium also chelates and eliminates zinc from the body. Edetate calcium also binds cadmium, copper, iron and manganese, but to a much lesser extent than either lead or zinc. Edetate calcium is relatively ineffective for use in treating mercury, gold or arsenic poisoning. show less «
Mechanism of Action:	The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are n... show more » The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased. show less «
Absorption:	Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection.
Biotransformation:	Almost none of the compound is metabolized.
Route of elimination:	It is excreted primarily by the kidney, with about 50% excreted in one hour and over 95% within 24 hours.2 Almost none of the compound is metabolized.
Half Life:	The half life of edetate calcium disodium is 20 to 60 minutes.
Toxicity:	Inadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency.
Affected organisms:	Humans and other mammals

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