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PubChem
| Name: | Dihematoporphyrin Ether |
|---|---|
| PubChem Compound ID: | 3086257 |
| Description: | The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States. |
| Molecular formula: | C34H38N4NaO5+ |
| Molecular weight: | 605.679 g/mol |
| Synonyms: |
DHE; CL 184,116; Porfimer sodium; Porfimer sodium [USAN:BAN:INN]; Porfimer sodico [INN-Spanish]; Porfimere sodique [INN-French]; Photofrin 2; Porfimerum natricum [INN-Latin]; Photofrin II; 87806-31-3.
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DrugBank
Identification
| Name: | Dihematoporphyrin Ether |
|---|---|
| Name (isomeric): | DB00707 |
| Drug Type: | small molecule |
| Description: | The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States. |
| Synonyms: |
DHE; Porfimer sodium; Dihematoporphyrin ether; DHP ether
|
| Brand: | Photofrin |
| Category: | Photosensitizing Agents, Antineoplastic Agents, Dermatologic Agents, Antiviral Agents |
| CAS number: | 87806-31-3 |
Pharmacology
| Indication: | Indicated in the treatment of esophageal cancer. |
|---|---|
| Pharmacology: |
Porfimer is a photosensitizing agent used in the photodynamic therapy (PDT) of tumors. Porfimer is indicated for the palliation of patients with completely obstructing esophageal cancer, or of patients with partially obstructing esophageal cancer who cannot be satisfactorily treated with Nd:YAG laser therapy, reduction of obstruction and palliation...
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| Mechanism of Action: |
Cellular damage caused by porfimer is a consequence of the propagation of radical reactions. Radical initiation may occur after porfimer absorbs light to form a porphyrin excited state. Spin transfer from porfimer to molecular oxygen may then generate singlet oxygen. Subsequent radical reactions can form superoxide and hydroxyl radicals. Tumor deat...
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| Protein binding: | ~90% |
| Half Life: | 10-452 hours |
| Clearance: | Renal cl=199.7 +/- 56.9 mL/min [Healthy subjects receiving a single 300-mg oral dose] |
| Affected organisms: | Humans and other mammals |
Targets
