QuickView for ezrin (gene)

Gene Symbol:

EZR Homo sapiens

Full name:

ezrin

Synonyms:

CVIL, CVL, HEL-S-105, VIL2, ezrin, cytovillin 2, epididymis secretory protein Li 105, p81, villin 2 (ezrin)

Genomic Location:

Chr 6: 159106764-159159247

Description:

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organiz...

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The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGCCAT_MIR183 ,  AAAGGGA_MIR204_MIR211 ,  IRF1_Q6 ,  GCCATNTTG_YY1_Q6 ,  GTGCCAA_MIR96

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

6q25.3

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