QuickView for fibronectin 1 (gene)

Gene Symbol:

FN1 Homo sapiens

Full name:

fibronectin 1

Synonyms:

CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF, fibronectin, cold-insoluble globulin, migration-stimulating factor

Genomic Location:

Chr 2: 215933422-216009036

Description:

This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesi...

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This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  ATGCAGT_MIR217 ,  STAT4_01 ,  AP3_Q6 ,  TTTTGAG_MIR373 ,  CTACTGT_MIR199A ,  AAANWWTGC_UNKNOWN ,  STAT6_01 ,  WTGAAAT_UNKNOWN ,  STAT_Q6 ,  TATAAA_TATA_01 ,  SOX9_B1 ,  ACATTCC_MIR1_MIR206 ,  CAGGTA_AREB6_01 ,  STAT5A_03 ,  CTCTGGA_MIR520A_MIR525 ,  AAAGACA_MIR511 ,  STAT_01 ,  TTGTTT_FOXO4_01 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  TTCYNRGAA_STAT5B_01 ,  TGATTTRY_GFI1_01 ,  SRY_02 ,  ACAWYAAAG_UNKNOWN ,  CTCCAAG_MIR432

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-217

Cytogenetic Map:

2q35

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