QuickView for fludrocortisone (compound)

Summary
General Info

PubChem

PubChem Compound 31378

Name:	Fludrocortisone
PubChem Compound ID:	31378
Description:	A synthetic mineralocorticoid with anti-inflammatory activity.
Molecular formula:	C₂₁H₂₉FO₅
Molecular weight:	380.45 g/mol
Synonyms:	Fludrocortisonum [INN-Latin]; Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11beta)-; Corticosterone, 9-fluoro-17-hydroxy-; Fludrocortisona [INN-Spanish]; 9 alpha FF; 9-AFH; Fluohydrocortisone; 9-alpha-Fluorohydrocortisone; Pregn-4-ene-3,20-dione, 9-fluoro-11,17, 21-trihydroxy-, (11.beta.)-; 9-Fluoro-11.beta.,17,21-trihydroxypregn-4-ene-3,20-dione. show more » Fludrocortisonum [INN-Latin]; Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11beta)-; Corticosterone, 9-fluoro-17-hydroxy-; Fludrocortisona [INN-Spanish]; 9 alpha FF; 9-AFH; Fluohydrocortisone; 9-alpha-Fluorohydrocortisone; Pregn-4-ene-3,20-dione, 9-fluoro-11,17, 21-trihydroxy-, (11.beta.)-; 9-Fluoro-11.beta.,17,21-trihydroxypregn-4-ene-3,20-dione; Pregn-4-ene-3,20-dione, 9-fluoro-11.beta.,17, 21-trihydroxy-; 9-AF; ZK5; U 5963; 9.alpha.-Fluoro-17-hydroxycorticosterone; Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-; Fluohydrisone; 9-Fluorocortisol; 9alpha-Fludrocortisone; Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy- (8CI); 9.alpha.-Fluorocortisol; F-COL; Fludrone; 9alpha-Fluoro-17-hydroxycorticosterone; Prestwick_648; BRN 3014278; Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-; Cortisol, 9-fluoro-; Fludrocortone; NSC11318; 127-31-1; Alflorone; Fluorocortisone; 9 .alpha. FF; Fludrocortisone; Fluodrocortisone; 4-08-00-03427 (Beilstein Handbook Reference); 9-Fluorohydrocortisone; Fludronef; HSDB 3332; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione; Fluorocortisol; Florinef; 9-alpha-Fluoro-17-hydroxycorticosterone; 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9-alpha-Fluorocortisol; Astonin-H; StC 1400; 9alpha-Fluorocortisol; F-Cortef; 9.alpha.-Fluoro-11.beta.,17.alpha.,21-trihydroxy-4-pregnene-3, 20-dione; 9.alpha.-Fluorohydrocortisone; 9-Fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9-alpha-Fludrocortisone; EINECS 204-833-2; C07004; NSC 11318; 9alpha-Fluoro-hydrocortisone show less «

DrugBank

Identification

Name:	Fludrocortisone
Name (isomeric):	DB00687
Drug Type:	small molecule
Description:	A synthetic mineralocorticoid with anti-inflammatory activity.
Brand:	Fluorocortisol, 9 alpha-Fludrocortisone, Fluorocortisone, Fluohydrisone, 9 .Alpha. Ff, 9 Alpha Ff, Alflorone, Fludronef, Fludrocortisona [INN-Spanish], Fludrone, Fludrocortisonum [INN-Latin], 9.Alpha.-Fluorohydrocortisone, F-Cortef, Florinef, Fluohydrocortisone, Fludrocortisone Acetate, Fludrocortone, 9 alpha-Fluorocortisol, F-COL, ZK5, 9.Alpha.-Fluorocortisol, Fluodrocortisone, Astonin-H
Category:	Adrenergic Agents, Anti-inflammatory Agents
CAS number:	127-31-1

Pharmacology

Indication:	For partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenogenital syndrome.
Pharmacology:	Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic acti... show more » Fludrocortisone is a synthetic adrenocortical steroid possessing very potent mineralocorticoid properties and high glucocorticoid activity. It is indicated as partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison’s disease and for the treatment of salt-losing adrenogenital syndrome. The physiologic action of fludrocortisone acetate is similar to that of hydrocortisone. However, the effects of fludrocortisone acetate, particularly on electrolyte balance, but also on carbohydrate metabolism, are considerably heightened and prolonged. Mineralocorticoids act on the distal tubules of the kidney to enhance the reabsorption of sodium ions from the tubular fluid into the plasma; they increase the urinary excretion of both potassium and hydrogen ions. show less «
Mechanism of Action:	Fludrocortisone binds the mineralocorticoid receptor (aldosterone receptor). This binding (or activation of the mineralocorticoid receptor by fludrocortisone) in turn causes an increase in ion and water transport and thus raises extracellular fluid volume and blood pressure and lowers potassium levels.
Protein binding:	High
Biotransformation:	Hepatic, some renal.
Half Life:	3.5 hours
Toxicity:	Effects of overexposure include irritation, cardiac edema, increased blood volume, hypertension, cardiac arrhythmias, enlargement of the heart, headaches, and weakness of the extremities.
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Take with food to reduce irritation.

Avoid excess salt/sodium unless otherwise instructed by your physician.

Drug interaction:

Fosphenytoin	The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, fludrocortisone.
Anisindione	The corticosteroid, fludrocortisone, alters the anticoagulant effect of anisindione.
Acenocoumarol	The corticosteroid, fludrocortisone, alters the anticoagulant effect, acenocoumarol.
Bismuth Subsalicylate	The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, bismuth subsalicylate.
Primidone	The barbiturate, primidone, may decrease the effect of the corticosteroid, fludrocortisone.

Fosphenytoin	The enzyme inducer, fosphenytoin, may decrease the effect of the corticosteroid, fludrocortisone.
Anisindione	The corticosteroid, fludrocortisone, alters the anticoagulant effect of anisindione.
Acenocoumarol	The corticosteroid, fludrocortisone, alters the anticoagulant effect, acenocoumarol.
Bismuth Subsalicylate	The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, bismuth subsalicylate.
Primidone	The barbiturate, primidone, may decrease the effect of the corticosteroid, fludrocortisone.
Phenytoin	The enzyme inducer, phenytoin, may decrease the effect of the corticosteroid, fludrocortisone.
Amobarbital	The barbiturate, amobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Ethotoin	The enzyme inducer, ethotoin, may decrease the effect of the corticosteroid, fludrocortisone.
Trisalicylate-choline	The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, trisalicylate-choline.
Salsalate	The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, salsalate.
Pentobarbital	The barbiturate, pentobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Edrophonium	The corticosteroid, fludrocortisone, may decrease the effect of the anticholinesterase, edrophonium.
Tacrine	Tacrine and Fludrocortisone may independently exacerbate muscle weakness in myasthenia gravis patients. Monitor for additive muscle weakness effects.
Vecuronium	Vecuronium may increase the adverse neuromuscular effects of systemic corticosteroids, such as Fludrocortisone. Monitor for increased muscle weakness and signs of polyneuropathies and myopathy.
Talbutal	The barbiturate, talbutal, may decrease the effect of the corticosteroid, fludrocortisone.
Aprobarbital	The barbiturate, aprobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Hexobarbital	The barbiturate, hexobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Neostigmine	The corticosteroid, fludrocortisone, may decrease the effect of the anticholinesterase, neostigmine.
Quinidine barbiturate	The barbiturate, quinidine barbiturate, may decrease the effect of the corticosteroid, fludrocortisone.
Heptabarbital	The barbiturate, heptabarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Phenobarbital	The barbiturate, phenobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Salicylate-sodium	The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, salicylate-sodium.
Acetylsalicylic acid	The corticosteroid, fludrocortisone, may decrease the effect of the salicylate, acetylsalicylic acid.
Methohexital	The barbiturate, methohexital, may decrease the effect of the corticosteroid, fludrocortisone.
Ambenonium	The corticosteroid, fludrocortisone, may decrease the effect of the anticholinesterase, ambenonium.
Rifampin	The enzyme inducer, rifampin, may decrease the effect of the corticosteroid, fludrocortisone.
Butalbital	The barbiturate, butalbital, may decrease the effect of the corticosteroid, fludrocortisone.
Butethal	The barbiturate, butethal, may decrease the effect of the corticosteroid, fludrocortisone.
Mephenytoin	The enzyme inducer, mephenytoin, may decrease the effect of the corticosteroid, fludrocortisone.
Secobarbital	The barbiturate, secobarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Pyridostigmine	The corticosteroid, fludrocortisone, may decrease the effect of the anticholinesterase, pyridostigmine.
Magnesium salicylate	The corticosteroid, fludrocortisone, may decrease the effect of magnesium salicylate.
Warfarin	The corticosteroid, fludrocortisone, alters the anticoagulant effect of warfarin.
Midodrine	Increased arterial pressure
Dicumarol	The corticosteroid, fludrocortisone, alters the anticoagulant effect of dicumarol.
Butabarbital	The barbiturate, butabarbital, may decrease the effect of the corticosteroid, fludrocortisone.
Dihydroquinidine barbiturate	The barbiturate, dihydroquinidine barbiturate, may decrease the effect of the corticosteroid, fludrocortisone.
Methylphenobarbital	The barbiturate, methylphenobarbital, may decrease the effect of the corticosteroid, fludrocortisone.

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Targets

Mineralocorticoid receptor

Glucocorticoid receptor

Androgen receptor