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QuickView for fluorescein (compound)
PubChem
| Name: | Fluorescein |
|---|---|
| PubChem Compound ID: | 10608 |
| Description: | A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275) |
| Molecular formula: | C20H10Na2O5 |
| Molecular weight: | 376.27 g/mol |
| Synonyms: |
Certiqual fluoresceine; 12417 Yellow; Resorcinol phthalein sodium; 2321-07-5; Uranine A Extra; D&C Yellow No. 8; Soluble Fluoresceine BPS; CI 45350; Fluor-I-strip A.T.; Sodium fluoresceinate.
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DrugBank
Identification
| Name: | Fluorescein |
|---|---|
| Name (isomeric): | DB00693 |
| Drug Type: | small molecule |
| Description: | A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275) |
| Synonyms: |
2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid
|
| Brand: | Fluorescein sodium, Eosin, Fluorescein disodium salt dihydrate, Acid Yellow 73, Uranin, Fluorescite, Uranine, Funduscein-25, Fluorescein acid, Fluorescein disodium salt, Fluorescein, Disodium Salt, Fluorescein, disodium salt, Fluorescein Sodium salt |
| Brand name mixture: | Fluress(Benoxinate Hydrochloride + Fluorescein Sodium), Fluorescein Sodium & Benoxinate Hydrochloride Ophtalmic Solution, Usp(Benoxinate Hydrochloride + Fluorescein Sodium), Fluress Liq Oph(Benoxinate Hydrochloride + Fluorescein Sodium), Fluoracaine Oph Soln(Fluorescein Sodium + Proxymetacain Hcl) |
| Category: | Fluorescent Dyes, Contrast Media |
| CAS number: | 2321-07-5 |
Pharmacology
| Indication: | For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature. |
|---|---|
| Mechanism of Action: |
Fluorescein sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescein is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from...
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| Absorption: | Rapidly distributed |
| Protein binding: | 85% |
| Route of elimination: | Fluorescein and its metabolites are mainly eliminated via renal excretion. |
| Clearance: | renal cl=1.75 mL/min/kg [After IV administration] hepatic cl=1.50 mL/min/kg [After IV administration] |
| Affected organisms: | Humans and other mammals |
Targets
Enzymes
Transporters
