QuickView for fmo2 (gene)

Gene Symbol:

FMO2 Homo sapiens

Full name:

flavin containing monooxygenase 2

Synonyms:

FMO1B1, dimethylaniline monooxygenase [N-oxide-forming] 2, FMO, pulmonary, dimethylaniline oxidase 2, flavin containing monooxygenase 2 (non-functional), pulmonary flavin-containing monooxygenase 2

Genomic Location:

Chr 1: 169421012-169448446

Description:

This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no ...

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This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBP_Q2_01 ,  GGGAGGRR_MAZ_Q6 ,  CEBPB_02 ,  TCTCTCC_MIR185 ,  SMAD4_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-185

Cytogenetic Map:

1q24.3

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