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QuickView for forkhead box O1 (gene)


Gene Symbol:
FOXO1 Homo sapiens Homo sapiens
Full name:
forkhead box O1
Synonyms:
FKH1, FKHR, FOXO1A, forkhead box protein O1, forkhead box protein O1A, forkhead, Drosophila, homolog of, in rhabdomyosarcoma
Genomic Location:
Chr 13: 40027801-40138734
Description:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 13
13q14.11


Transcripts Names
NM_002015
XM_011535008
XM_011535010
Protein Names
Q5VYC7
Q6NSK6
Q12778
O43523



GO Molecular Function

sequence-specific DNA binding | beta-catenin binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein phosphatase 2A binding | enzyme binding | nucleic acid binding | transcription coactivator binding | chromatin binding | ubiquitin-like protein ligase binding | DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | protein phosphatase binding | transcription factor binding | ubiquitin protein ligase binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | phosphatase binding | transcription cofactor binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | response to extracellular stimulus | regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter | negative regulation of phosphorylation | cellular response to increased oxygen levels | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | response to nutrient levels | negative regulation of MAPK cascade | response to cytokine | positive regulation of apoptotic process | regulation of carbohydrate metabolic process | regulation of programmed cell death | regulation of autophagy | response to hormone | cellular response to hyperoxia | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | response to dexamethasone | negative regulation of RNA biosynthetic process | cell differentiation | negative regulation of fat cell differentiation | cellular response to extracellular stimulus | positive regulation of protein catabolic process | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter | glucose homeostasis | response to antibiotic | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | cellular response to cold | cellular homeostasis | odontogenesis | negative regulation of signaling | cellular response to nitric oxide | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | negative regulation of apoptotic process | tooth mineralization | cellular response to starvation | positive regulation of nitrogen compound metabolic process | response to inorganic substance | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of fat cell differentiation | regulation of cell differentiation | response to hydrogen peroxide | negative regulation of muscle hypertrophy | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | endocrine pancreas development | response to stimulus | vasculature development | positive regulation of protein metabolic process | response to cold | cellular response to xenobiotic stimulus | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | multicellular organismal homeostasis | response to peptide | response to starvation | programmed cell death | cellular response to inorganic substance | cardiovascular system development | response to temperature stimulus | cellular nitrogen compound metabolic process | cellular response to toxic substance | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | macromolecule modification | blood vessel development | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | cellular response to antibiotic | multicellular organism development | protein acetylation | cellular glucose homeostasis | cellular response to peptide hormone stimulus | regulation of MAPK cascade | cellular response to DNA damage stimulus | cellular response to insulin stimulus | cellular response to oxidative stress | regulation of phosphorylation | positive regulation of gluconeogenesis | regulation of gene expression | pancreas development | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | insulin receptor signaling pathway | positive regulation of cellular metabolic process | animal organ morphogenesis | negative regulation of cardiac muscle hypertrophy | amelogenesis | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | cytokine-mediated signaling pathway | response to corticosteroid | regulation of transcription by RNA polymerase II | fat cell differentiation | response to oxidative stress | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | cellular response to cytokine stimulus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | cellular response to glucocorticoid stimulus | response to hyperoxia | negative regulation of stress-activated MAPK cascade | response to toxic substance | response to xenobiotic stimulus | endocrine system development | cellular response to corticosteroid stimulus | autophagy | cellular response to drug | energy homeostasis | regulation of cardiac muscle hypertrophy in response to stress | cell communication | regulation of cellular metabolic process | odontogenesis of dentin-containing tooth | regulation of protein metabolic process | homeostatic process | regulation of protein phosphorylation | regulation of RNA metabolic process | neuronal stem cell population maintenance | negative regulation of cardiac muscle hypertrophy in response to stress | protein metabolic process | regulation of cardiac muscle hypertrophy | DNA-binding transcription factor activity | response to organic substance | cellular response to reactive nitrogen species | response to antineoplastic agent | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | response to insulin | anatomical structure development | cell surface receptor signaling pathway | regulation of glucose metabolic process | regulation of neural precursor cell proliferation | metabolic process | positive regulation of glucose metabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | cellular response to hydrogen peroxide | chemical homeostasis | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | maintenance of cell number | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | response to reactive oxygen species | negative regulation of cellular protein metabolic process | gene expression | positive regulation of programmed cell death | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | biomineral tissue development | cellular response to steroid hormone stimulus | negative regulation of cardiac muscle adaptation | positive regulation of autophagy | transcription, DNA-templated | cellular response to dexamethasone stimulus | temperature homeostasis | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | positive regulation of carbohydrate metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular protein metabolic process | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of developmental process | developmental process | negative regulation of canonical Wnt signaling pathway | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of gluconeogenesis | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | response to fluoride | cellular metabolic process | cellular response to organic substance | enamel mineralization | regulation of cell death | response to nitric oxide | response to steroid hormone | negative regulation of cell death | circulatory system development | carbohydrate homeostasis | negative regulation of cell differentiation | signal transduction | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular