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QuickView for gatifloxacin (compound)


PubChem
Name: gatifloxacin
PubChem Compound ID: 1150508
Molecular formula: C19H22FN3O4
Molecular weight: 375.394 g/mol
DrugBank
Identification
Name: gatifloxacin
Name (isomeric): DB01044
Drug Type: small molecule
Brand: Zymar, Tequin
Category: Anti-Infective Agents, Quinolones, Antibiotics
CAS number: 112811-59-3
Pharmacology
Indication: For the treatment of bronchitis, sinusitis, community-acquired pneumonia, and skin infections (abscesses, wounds) caused by S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, S. pyogenes
Pharmacology:
Gatifloxacin is a synthetic broad-spectrum 8-methoxyfluoroquinolone antibacterial agent for oral or intravenous administration. is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Not...
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Mechanism of Action: The bactericidal action of Gatifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
Absorption: Well absorbed from the gastrointestinal tract after oral administration with absolute bioavailability of gatifloxacin is 96%
Protein binding: 20%
Biotransformation: Gatifloxacin undergoes limited biotransformation in humans with less than 1% of the dose excreted in the urine as ethylenediamine and methylethylenediamine metabolites
Half Life: 7-14 hours
Affected organisms: Enteric bacteria and other eubacteria
Interactions
Food interaction:
Drink liberally.
Absorption does not seem to be affected by milk or calcium carbonate, however, gatifloxacin bioavailability appears significantly reduced when combined with Ensure™ (Cmax is reduced by about 50% while total drug exposure (AUC) is reduced by about 25%).
Take without regard to meals.
Drug interaction:
DisopyramideIncreased risk of cardiotoxicity and arrhythmias
PromazineIncreased risk of cardiotoxicity and arrhythmias
TriflupromazineIncreased risk of cardiotoxicity and arrhythmias
IronFormation of non-absorbable complexes
ChlorpromazineIncreased risk of cardiotoxicity and arrhythmias
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