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QuickView for gelsolin (gene)


Gene Symbol:
GSN Homo sapiens Homo sapiens
Full name:
gelsolin
Synonyms:
ADF, AGEL, gelsolin, actin-depolymerizing factor, brevin
Genomic Location:
Chr 9: 123070201-123134941
Description:
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several differe...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: miRecords):
Cytogenetic Map:
chr 9
9q33.2





GO Molecular Function

actin binding | actin filament binding | cation binding | protein-containing complex binding | myosin binding | cytoskeletal protein binding | ion binding | myosin II binding | protein binding | calcium ion binding | metal ion binding

GO Biological Process

response to extracellular stimulus | regulation of supramolecular fiber organization | regulation of cysteine-type endopeptidase activity | response to nutrient levels | actin filament-based process | exocytosis | extracellular structure organization | response to cytokine | positive regulation of cellular component organization | neutrophil activation | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | phagocytosis, engulfment | regulation of localization | regulation of programmed cell death | negative regulation of protein complex disassembly | actin cytoskeleton organization | epithelial cell apoptotic process | establishment of localization | regulation of immune system process | negative regulation of cellular process | response to metal ion | regulation of protein localization to membrane | cell differentiation | defense response | nervous system development | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | response to drug | actin nucleation | neurogenesis | regulation of organelle organization | regulation of actin polymerization or depolymerization | striated muscle atrophy | membrane organization | response to antibiotic | response to folic acid | cellular process | secretion | positive regulation of actin filament polymerization | leukocyte degranulation | localization | developmental growth | negative regulation of viral life cycle | macromolecule localization | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | positive regulation of epithelial cell apoptotic process | tissue development | regeneration | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | gliogenesis | regulation of protein complex assembly | positive regulation of cellular protein metabolic process | cellular component organization | regulation of establishment of cell polarity | cellular response to metal ion | cellular response to interferon-gamma | regulation of actin filament length | positive regulation of protein processing | response to stimulus | positive regulation of protein processing in phagocytic vesicle | regulation of cellular protein localization | neutrophil degranulation | oligodendrocyte development | actin filament reorganization | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to stress | leukocyte activation involved in immune response | positive regulation of cysteine-type endopeptidase activity | programmed cell death | protein destabilization | phosphatidylinositol-mediated signaling | supramolecular fiber organization | cellular response to inorganic substance | cellular localization | secretion by cell | response to alcohol | cellular response to cadmium ion | positive regulation of proteolysis | actin filament polymerization | extracellular matrix organization | regulation of cellular component size | cellular component assembly | actin filament severing | regulation of protein processing | regulation of cell adhesion | positive regulation of actin nucleation | regulation of establishment or maintenance of cell polarity | response to ethanol | actin filament capping | response to nitrogen compound | apoptotic process | organelle assembly | system development | regulation of viral entry into host cell | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | regulation of protein stability | regulation of actin cytoskeleton organization | multicellular organism development | regulation of peptidase activity | regulation of actin filament organization | actin filament organization | leukocyte mediated immunity | regulation of catalytic activity | amyloid fibril formation | regulation of protein complex disassembly | wound healing | regulation of T cell activation | regulation of gene expression | cell projection assembly | positive regulation of cellular metabolic process | regulation of lymphocyte activation | negative regulation of actin filament polymerization | regulation of nitrogen compound metabolic process | actin polymerization or depolymerization | regulation of cysteine-type endopeptidase activity involved in apoptotic process | renal absorption | protein polymerization | positive regulation of protein complex assembly | vesicle-mediated transport | response to nutrient | positive regulation of hydrolase activity | negative regulation of viral process | regulation of receptor clustering | cellular response to cytokine stimulus | response to cadmium ion | positive regulation of keratinocyte apoptotic process | regulation of cellular protein metabolic process | glial cell differentiation | hepatocyte apoptotic process | regulated exocytosis | positive regulation of endopeptidase activity | cellular protein-containing complex assembly | inositol lipid-mediated signaling | response to toxic substance | regulation of apoptotic signaling pathway | regulation of epithelial cell apoptotic process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of plasma membrane raft polarization | maintenance of protein location | cell communication | regulation of cellular metabolic process | regulation of actin filament polymerization | regulation of actin filament depolymerization | regulation of keratinocyte apoptotic process | cell activation involved in immune response | positive regulation of cytoskeleton organization | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | regulation of viral process | regulation of protein depolymerization | positive regulation of molecular function | protein-containing complex assembly | regulation of podosome assembly | protein metabolic process | negative regulation of protein polymerization | response to organic substance | negative regulation of viral entry into host cell | response to wounding | import into cell | anatomical structure development | cell projection organization | metabolic process | positive regulation of supramolecular fiber organization | negative regulation of cytoskeleton organization | cellular protein localization | oligodendrocyte differentiation | membrane invagination | actin cytoskeleton reorganization | endocytosis | positive regulation of cell death | immune response | regulation of actin nucleation | negative regulation of protein complex assembly | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | response to vitamin | cilium assembly | regulation of cell activation | muscle atrophy | positive regulation of programmed cell death | maintenance of protein location in cell | barbed-end actin filament capping | cytoskeleton organization | renal system process | response to interferon-gamma | cell activation | cilium organization | negative regulation of actin filament depolymerization | regulation of cell communication | positive regulation of protein maturation | signaling | glial cell development | response to organic cyclic compound | cell development | protein localization | cellular protein metabolic process | regulation of endopeptidase activity | cellular macromolecule localization | developmental process | organelle organization | sequestering of actin monomers | innate immune response | positive regulation of protein polymerization | neutrophil mediated immunity | response to organonitrogen compound | negative regulation of supramolecular fiber organization | central nervous system development | positive regulation of metabolic process | regulation of actin filament-based process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of organelle assembly | regulation of viral life cycle | aging | tissue regeneration | phagocytosis | extracellular matrix disassembly | regulation of cellular component organization | regulation of establishment of T cell polarity | positive regulation of apoptotic signaling pathway | regulation of cytoskeleton organization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | maintenance of location in cell | multicellular organismal process | renal protein absorption

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | ruffle | adherens junction | focal adhesion | cytoplasmic vesicle | cell | lamellipodium | cytoplasmic vesicle lumen | cytoplasm | cortical cytoskeleton | cell-substrate junction | intracellular organelle | actin cytoskeleton | ficolin-1-rich granule lumen | protein-containing complex | cell projection | secretory vesicle | endomembrane system | plasma membrane | cell leading edge | vesicle | podosome | perinuclear region of cytoplasm | extracellular exosome | cytoplasmic region | actin cap | cortical actin cytoskeleton | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | sarcoplasm | extracellular space | cell periphery | membrane-enclosed lumen | cell-substrate adherens junction | secretory granule lumen | blood microparticle | cytosol | intracellular vesicle | cytoskeleton | endocytic vesicle | intracellular | cell junction | myelin sheath | membrane | vesicle lumen | phagocytic vesicle