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QuickView for glyceryl trinitrate (compound)


PubChem
Name: Nitroglycerin
PubChem Compound ID: 4510
Description: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Molecular formula: C3H5N3O9
Molecular weight: 227.087 g/mol
Synonyms:
Glycerol (trinitrate de) [French]; trinitroglycerol; Nitromint; Nitroprontan; Spirit of glonoin; Suscard; Nitro-Gesanit Retard; Nitroglicerina [Italian]; Glycerol Nitric Acid Triester; Polnitrin.
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DrugBank
Identification
Name: Nitroglycerin
Name (isomeric): DB00727
Drug Type: small molecule
Description: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Synonyms:
Trinitroglycerin; nitroglycerin ointment; NTG; Nitroglycerine; Glyceryl trinitrate; NG; TNG
Brand: Minitran, Nitrolingual Pump Spray, Nitrocap, Nitrospan, Nitro-Dur, Cellegesic, Nitrostat, Rectogesic, Nitrong parenteral, Nitronet, Transderm Nitro, Tridil, Natispray
Brand name mixture:
Homeo-form MI - liquid(aluminum oxide + antimony trisulfide + cyclamen europaeum l. + lycopodium clavatum + melilot + nitroglycerin + silver nitrate), Nova 7025 - liq(aconite + apis mellifica + arnica montana + barberry root + calendula + cantharides + charcoal activated + echinacea angustifolia + hahnemann's causticum + hypericum perforatum + n...
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Category: Nitrates and Nitrites, Vasodilator Agents, Tocolytic Agents, Explosive Agents
CAS number: 55-63-0
Pharmacology
Indication: For the prevention of angina
Pharmacology: Nitroglycerin, an organic nitrate, is available in many forms as a vasodilator. Nitroglycerin is used in the treatement of angina pectoris and perioperative hypertension, to produce controlled hypotension during surgical procedures, to treat hypertensive emergencies, and to treat congestive heart failure associated with myocardial infarction.
Mechanism of Action:
Similar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle ce...
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Biotransformation: Hepatic, cytochrome P450 (P450) is a key enzyme of organic nitrate biotransformation
Half Life: 3 minutes
Clearance: 1 L/kg/min
Toxicity: Increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol.
Take on empty stomach: 1 hour before or 2 hours after meals.
Dissolve under the tongue.
Drug interaction:
DihydroergotoxinePossible antagonism of action
VardenafilThe vasodilatory effects of Nitroglycerin may be increased by Vardenafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
ErgotaminePossible antagonism of action
MethylergonovinePossible antagonism of action
TadalafilThe vasodilatory effects of Nitroglycerin may be increased by Tadalafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
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