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QuickView for glycopyrrolate (compound)

Summary
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PubChem

PubChem Compound 11693

PubChem Compound 11693

Name:	Glycopyrrolate
PubChem Compound ID:	11693
Description:	A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
Molecular formula:	C₁₉H₂₈BrNO₃
Molecular weight:	398.335 g/mol
Synonyms:	596-51-0; AHR 504; Pyrrolidinium, 1,1-dimethyl-3-hydroxy-, bromide, alpha-cyclopentylmandelate; Glycopyrrolate bromide; Gastrodyn; Glycopyrronii bromidum; Ritropirronium bromide [INN]; 3-Hydroxy-1,1-dimethylpyrrolidinium bromide alpha-cyclopentylmandelate; Bromure de glycopyrronium [INN-French]; 53808-86-9. show more » 596-51-0; AHR 504; Pyrrolidinium, 1,1-dimethyl-3-hydroxy-, bromide, alpha-cyclopentylmandelate; Glycopyrrolate bromide; Gastrodyn; Glycopyrronii bromidum; Ritropirronium bromide [INN]; 3-Hydroxy-1,1-dimethylpyrrolidinium bromide alpha-cyclopentylmandelate; Bromure de glycopyrronium [INN-French]; 53808-86-9; Bromure de ritropirronio; 1,1-Dimethyl-3-hydroxypyrrolidinium bromide alpha-cyclopentylmandelate; EINECS 209-887-0; NSC 251251; NSC 251252; 1-Methyl-3-pyrrolidyl alpha-phenylcyclopentaneglycolate methobromide; Glycopyrroni bromidum; 3-(erythro-2-Cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidiniumbromid; Robinul; Nodapton; Pyrrolidinium, 3-((cyclopentylhydroxyphenylacetyl)oxy)-1,1-dimethyl-, bromide; Tarodyn; Asecryl; Tarodyl; Ritropirronium bromide; Glycopyrrolate [USAN]; D00540; Glycopyrrolate; Bromuro de glicopirronio [INN-Spanish]; NSC 250836; Glycopyrronium bromide (JAN); Pyrrolidinium, 3-hydroxy-1,1-dimethyl-, bromide, alpha-cyclopentylmandelate (8CI); Glycopyrronium bromide; Glycopyrronii bromidum [INN-Latin]; Glycopyrrolate (USP); Robinul (TN); Bromure de ritropirronium; erythro-3-Hydroxy-1,1-dimethylpyrrolidinium bromide alpha-cyclopentylmandelate. show less «

DrugBank

Identification

Name:	Glycopyrrolate
Name (isomeric):	DB00986
Drug Type:	small molecule
Description:	A muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
Synonyms:	Glycopyrronium bromide
Brand:	Robinul, Robinal, Asecryl, Robanul, Tarodyl, Tarodyn, Nodapton, Gastrodyn
Category:	Muscarinic Antagonists, Adjuvants, Anesthesia, Anti-cholinergic Agents
CAS number:	596-51-0

Pharmacology

Indication:	For use as a preoperative antimuscarinic to reduce salivary, tracheobronchial, and pharyngeal secretions, to reduce the volume and free acidity of gastric secretions and to block cardiac vagal inhibitory reflexes during induction of anesthesia and intubation.
Pharmacology:	Glycopyrrolate decreases acid secretion in the stomach. Hence it can be used for treating ulcers in the stomach and small intestine, in combination with other medications. In anesthesia, glycopyrrolate injection serves as a preoperative antimuscarinic operation that reduces salivary, tracheobronchial, and pharyngeal secretions, as well as decreases... show more » Glycopyrrolate decreases acid secretion in the stomach. Hence it can be used for treating ulcers in the stomach and small intestine, in combination with other medications. In anesthesia, glycopyrrolate injection serves as a preoperative antimuscarinic operation that reduces salivary, tracheobronchial, and pharyngeal secretions, as well as decreases the acidity of gastric secretions blocks cardiac vagal inhibitory reflexes during intubation show less «
Mechanism of Action:	Glycopyrrolate binds competitively to the muscarinic acetylcholine receptor. Like other anticholinergic (antimuscarinic) agents, it inhibits the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic rece... show more » Glycopyrrolate binds competitively to the muscarinic acetylcholine receptor. Like other anticholinergic (antimuscarinic) agents, it inhibits the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of smooth muscle, cardiac muscle, the sinoatrial node, the atrioventricular node, exocrine glands and, to a limited degree, in the autonomic ganglia. Thus, it diminishes the volume and free acidity of gastric secretions and controls excessive pharyngeal, tracheal, and bronchial secretions. show less «
Absorption:	Rapidly absorbed (1-2 minutes) after intravenous injection
Half Life:	0.6-1.2 hours
Toxicity:	Side effects include dry mouth, difficult urinating, heachaches, diarrhea and constipation. The medication also induces drowsiness or blurred vision. LD₅₀=709 mg/kg (rat, oral).
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Take without regard to meals.

Drug interaction:

Triprolidine	Triprolidine and Glycopyrrolate, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Donepezil	Possible antagonism of action
Trospium	Trospium and Glycopyrrolate, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Glycopyrrolate, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Rivastigmine	Possible antagonism of action

Targets

Muscarinic acetylcholine receptor M1