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QuickView for gmk (gene)


Gene Symbol:
GUK1 Homo sapiens Homo sapiens
Full name:
guanylate kinase 1
Synonyms:
GMK, guanylate kinase, ATP:GMP phosphotransferase, GMP kinase
Genomic Location:
Chr 1: 226394605-226403275
Description:
The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Bos taurus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 1
1q42.13





GO Molecular Function

nucleoside monophosphate kinase activity | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | nucleobase-containing compound kinase activity | organic cyclic compound binding | purine ribonucleoside triphosphate binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, phosphate group as acceptor | transferase activity | guanylate kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding

GO Biological Process

purine ribonucleotide metabolic process | GMP metabolic process | nucleoside monophosphate kinase activity | establishment of localization | GDP biosynthetic process | deoxyribonucleoside triphosphate metabolic process | cellular process | localization | protein transport | nucleotide metabolic process | ribose phosphate metabolic process | purine nucleotide biosynthetic process | macromolecule localization | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | nucleoside monophosphate phosphorylation | deoxyribonucleotide biosynthetic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | purine nucleotide metabolic process | cellular nitrogen compound biosynthetic process | dGMP metabolic process | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cellular biosynthetic process | purine nucleoside metabolic process | GDP metabolic process | nucleotide biosynthetic process | nitrogen compound metabolic process | phosphorus metabolic process | dGDP biosynthetic process | organic substance transport | organophosphate metabolic process | nucleotide phosphorylation | nucleoside metabolic process | deoxyribonucleotide metabolic process | small molecule metabolic process | peptide transport | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | phosphorylation | purine ribonucleotide biosynthetic process | nucleobase-containing compound kinase activity | phosphate-containing compound metabolic process | drug metabolic process | nucleobase-containing small molecule interconversion | nucleoside diphosphate metabolic process | metabolic process | GDP-mannose metabolic process | amide transport | nucleobase-containing compound metabolic process | nucleotide-sugar metabolic process | organic substance metabolic process | nucleoside diphosphate biosynthetic process | establishment of protein localization | guanylate kinase activity | ribose phosphate biosynthetic process | dATP metabolic process | protein localization | kinase activity | glycoprotein transport | carbohydrate derivative metabolic process | heterocycle metabolic process | cellular metabolic process | ATP metabolic process | carbohydrate derivative transport

GO Cellular Component

cell | cytoplasm | cytosol | intracellular