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Name: Platelet Glycoprotein GPIIb-IIIa Complex
Description: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
GPIIb-IIIa Receptors; Glycoproteins IIb IIIa; Integrin alpha IIb beta 3; alphaIIbbeta3, Integrin; Platelet Glycoprotein GPIIb IIIa Complex; GPIIb IIIa Receptors; beta-3, Integrin alpha-IIb; Receptors, GPIIb-IIIa; Glycoproteins IIb-IIIa; Integrin alphaIIbbeta3.
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