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PubChem
Name: Heroin
PubChem Compound ID: 15168
Description: A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)
Molecular formula: C21H24ClNO5
Molecular weight: 405.872 g/mol
Synonyms:
EINECS 216-124-5; Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, diacetate (ester), hydrochloride; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-, diacetate (ester), hydrochloride (9CI); NSC 302357; 1502-95-0; Diamorphine hydrochloride; Diacetylmorphine hydrochloride; Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-,; Heroine hydrochloride; Morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, diacetate (ester), hydrochloride (8CI).
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DrugBank
Identification
Name: Heroin
Name (isomeric): DB01452
Drug Type: small molecule
Description: A narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed)
Synonyms:
diacetylmorphine; Smack; diamorphine
Category: Narcotics, Analgesics, Analgesics, Opioid
CAS number: 561-27-3
Pharmacology
Indication: Used in the treatment of acute pain, myocardial infarction, acute pulmonary oedema, and chronic pain.
Pharmacology:
The onset of heroin's effects is dependent on the method of administration. Taken orally, heroin is totally metabolized in vivo into morphine before crossing the blood-brain barrier; so the effects are the same as oral morphine. Take by injection, heroin crosses into the brain. Once in the brain, heroin is rapidly metabolized into morphine by remov...
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Mechanism of Action:
Heroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals. Heroin, along with other opioids, are agonists to four endogenous neurotransmitters. They are beta-endorphin, dynorphin, leu-enkephalin, and met-enkephalin. The body responds t...
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Absorption: Bioavailability is less than 35%.
Protein binding: 0% (morphine metabolite 35%)
Biotransformation: Hepatic.
Route of elimination: 90% renal as glucuronides, rest biliary
Half Life: 2-3 hours
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol
To avoid constipation: increase your daily intake of fiber (beans, whole grains, vegetables).
Drug interaction:
CimetidineCimetidine increases the effect of the narcotic

Targets