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QuickView for hesperetin (compound)


PubChem
Name: hesperetin
PubChem Compound ID: 3593
Molecular formula: C16H14O6
Molecular weight: 302.279 g/mol
Synonyms:
Hesperetin; Flavanone, 3',5, 7-trihydroxy-4'-methoxy-; NSC61835; NSC641520; AIDS160644; Hesperitin; 520-33-2; NSC57654; 4H-1-Benzopyran-4-one, 2,3-dihydro-5, 7-dihydroxy-2- (3-hydroxy-4-methoxyphenyl)-, (S)-; 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one.
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DrugBank
Identification
Name: hesperetin
Name (isomeric): DB01094
Drug Type: small molecule
Synonyms:
YSO2; Hesperitin; Cyanidanon 4'-Methyl Ether 1626
Brand: Hesperin
Category: Anticholesteremic Agents
CAS number: 520-33-2
Pharmacology
Indication: For lowering cholesterol and, possibly, otherwise favorably affecting lipids. <i>In vitro</i> research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again.
Pharmacology: Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperetin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions.
Mechanism of Action:
Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and en...
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Affected organisms: Humans and other mammals

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