The TEAD family (also known as the TEF family) transcription factors play a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD transcription factors act by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction.Four TEAD genes exist in mammals (TEAD 1 to 4). TEAD4 protein (also known as TEF-3) was reported to regulate muscle-specific genes in cardiac and smooth muscle cells. Alternatively spliced transcripts for TEAD4 have been identified in human retinal vascular endothelial cells. TEAD4 protein has been shown to enhance VEGF gene expression in bovine aortic endothelial cells.