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QuickView for hydroxycobalamin (compound)


PubChem
Name: Hydroxocobalamin
PubChem Compound ID: 11622291
Description: Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.
Molecular formula: C62H90CoN13O15P
Molecular weight: 1347.36 g/mol
DrugBank
Identification
Name: Hydroxocobalamin
Name (isomeric): DB00200
Drug Type: small molecule
Description: Injectable form of VITAMIN B 12 that has been used therapeutically to treat VITAMIN B 12 DEFICIENCY.
Synonyms:
Hydroxocobalamin monohydrochloride; Vitamin B12a; Hydroxocobalamin Vitamin B12; Hydroxomin; Hydroxocobalaminacetat; Hydroxocobalamin acetate
Brand: Cyanokit, Hydroxy Cobal, Hydro Cobex, Acti-B12, Alpharedisol
Brand name mixture:
Magnum Plus Caplet(Beta-Carotene + Biotin + Calcium (Calcium Citrate, Calcium Fumarate, Calcium Malate, Calcium Succinate, Calcium Glutarate) + Choline (Choline Citrate) + Chromium (Chromium Citrate, Chromium Fumarate, Chromium Malate, Chromium Succinate, Chromium Glutarate) + Copper (Copper Citrate, Copper Fumarate, Copper Malate, Copper Succin...
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Category: Vitamin B Complex, Anti-anemic Agents, Hematinics, Nutritional Supplement
CAS number: 13422-51-0
Pharmacology
Indication: For treatment of pernicious anemia and the prevention and treatment of vitamin B12 deficiency arising from alcoholism, malabsorption, tapeworm infestation, celiac, hyperthyroidism, hepatic-biliary tract disease, persistent diarrhea, ileal resection, pancreatic cancer, renal disease, prolonged stress, vegan diets, macrobiotic diets or other restrictive diets. Also for the treatment of known or suspected cyanide poisoning.
Pharmacology:
Hydroxocobalamin is a synthetic, injectable form of Vitamin B12. Hydroxocobalamin is actually a precursor of two cofactors or vitamins (Vitamin B12 and Methylcobalamin) which are involved in various biological systems in man. Vitamin B12 is required for the conversion of methylmalonate to succinate. Deficiency of this enzyme could therefore interfe...
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Mechanism of Action:
Vitamin B12 exists in four major forms referred to collectively as cobalamins; deoxyadenosylcobalamin, methylcobalamin, hydroxocobalamin, and cyanocobalamin. Two of these, methylcobalamin and 5-deoxyadenosyl cobalamin, are primarily used by the body. Methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion ...
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Absorption: Readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Vitamin B12 is absorbed in the lower half of the ileum.
Protein binding: Very high (90%). Cobalamins are extensively bound to two specific plasma proteins called transcobalamin 1 and 2; 70% to transcobalamin 1, 5% to transcobalamin 2.
Biotransformation: Primarily hepatic. Cobalamins are absorbed in the ileum and stored in the liver. They continuously undergo enterohepatic recycling via secretion in the bile. Part of a dose is excreted in the urine, most of it in the first 8 hours.
Route of elimination: Each hydroxocobalamin molecule can bind one cyanide ion by substituting it for the hydroxo ligand linked to the trivalent cobalt ion, to form cyanocobalamin, which is then excreted in the urine.
Half Life: Approximately 6 days (peak plasma concentration after 8-12 hours from oral administration)
Affected organisms: Humans and other mammals

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