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QuickView for hydroxyurea (compound)

Name: Hydroxyurea
PubChem Compound ID: 3657
Description: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Molecular formula: CH4N2O2
Molecular weight: 76.0547 g/mol
Hydura; Hydroxycarbamidum [INN-Latin]; Hidroxicarbamida [INN-Spanish]; Carbamyl hydroxamate; EU-0100596; Hydroxycarbamine; KBio1_000556; HU; Hidrix; BRN 1741548.
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Name: Hydroxyurea
Name (isomeric): DB01005
Drug Type: small molecule
Description: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Carbamohydroximic Acid; N-Hydroxyurea; Hydroxycarbamide; Carbamohydroxamic Acid; Carbamoyl Oxime; Carbamohydroxyamic Acid; Hydroxicarbamidum; Sterile Urea; Hydroxycarbamine; HU.
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Brand: Hidrix, Biosupressin, Ureaphil, Hydurea, Litaler, Hydrea, Droxia, Hydura, Litalir, Onco-Carbide, Hydreia, Oxyurea
Category: Antisickling Agents, Antineoplastic Agents, Enzyme Inhibitors, Nucleic Acid Synthesis Inhibitors
CAS number: 127-07-1
Indication: For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xe...
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Mechanism of Action:
Hydroxyurea is converted to a free radical nitroxide (NO) in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active site of the M2 protein subunit of ribonucleotide reductase, inactivating the enzyme. The entire replicase complex, including ribonucleotide reductase, is inactivated and DNA synthesis is...
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Absorption: Well absorbed from the gastrointestinal tract.
Biotransformation: Hepatic.
Route of elimination: Renal excretion is a pathway of elimination.
Half Life: 3-4 hours
Toxicity: Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg Teratogenicity: Teratogenic effects have occurred in experimental animals.Hydroxyurea use during a small number of human pregnancies has been reported. Adverse effects have not been observed in any of the exposed newborns. Reproductive Effects: Adverse reproductive effects have occurred in experimental animals. Mutagenicity: Mutagenic effects have occurred in experimental animals.Mutagenic effects have occurred in humans.
Affected organisms: Humans and other mammals
Food interaction:
Take without regard to meals. Drink liberally.
Drug interaction:
TrastuzumabTrastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.